Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis
Abstract Research on neuronal and astroglial markers for predicting outcomes in aquaporin-4 antibody-seropositive neuromyelitis optica spectrum disorders (NMOSD) remains limited. We aimed to evaluate the prognostic value of blood biomarkers for neuronal and astroglial damage in NMOSD compared with m...
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Nature Portfolio
2025-04-01
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| author | Wangyong Shin Eun-Jae Lee Dayoung Seo Bum Joon Choi Inhye Jang Jin Hee Kim Lynkyung Choi Keonwoo Kim Ji-Yon Kim Hee-Jae Jung Hyemi Lee Hyunjin Kim Young-Min Lim |
| author_facet | Wangyong Shin Eun-Jae Lee Dayoung Seo Bum Joon Choi Inhye Jang Jin Hee Kim Lynkyung Choi Keonwoo Kim Ji-Yon Kim Hee-Jae Jung Hyemi Lee Hyunjin Kim Young-Min Lim |
| author_sort | Wangyong Shin |
| collection | DOAJ |
| description | Abstract Research on neuronal and astroglial markers for predicting outcomes in aquaporin-4 antibody-seropositive neuromyelitis optica spectrum disorders (NMOSD) remains limited. We aimed to evaluate the prognostic value of blood biomarkers for neuronal and astroglial damage in NMOSD compared with multiple sclerosis (MS). Patients with NMOSD and MS were prospectively recruited, and baseline serum levels of neurofilament light (sNfL) and glial fibrillary acidic protein (sGFAP) were measured. The correlations between these biomarkers and neurological disability (Expanded Disability Status Scale, EDSS) and cognitive function (iPad-based processing speed test, PST) were analyzed at baseline and two years later. In this cohort of 41 NMOSD and 92 MS patients, blood biomarkers demonstrated distinct patterns of association with current and future outcomes. In NMOSD, sGFAP was consistently linked to neurological disability and cognitive impairment over time, reflecting astrocytopathy with minimal silent neurodegeneration. In MS, sGFAP did not correlate with baseline EDSS but showed associations with future scores. Notably, sNfL was more strongly associated with future PST scores than baseline scores (p = 0.005), suggesting ongoing neurodegeneration. These results underscore that blood biomarkers are predictive of both current and future outcomes in NMOSD and MS, with differing patterns reflecting the unique pathogenesis of each disease. |
| format | Article |
| id | doaj-art-1d685d76886f49558b3ca170db25edb6 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-1d685d76886f49558b3ca170db25edb62025-08-20T03:07:40ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-95773-6Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosisWangyong Shin0Eun-Jae Lee1Dayoung Seo2Bum Joon Choi3Inhye Jang4Jin Hee Kim5Lynkyung Choi6Keonwoo Kim7Ji-Yon Kim8Hee-Jae Jung9Hyemi Lee10Hyunjin Kim11Young-Min Lim12Department of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Medicine, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineAbstract Research on neuronal and astroglial markers for predicting outcomes in aquaporin-4 antibody-seropositive neuromyelitis optica spectrum disorders (NMOSD) remains limited. We aimed to evaluate the prognostic value of blood biomarkers for neuronal and astroglial damage in NMOSD compared with multiple sclerosis (MS). Patients with NMOSD and MS were prospectively recruited, and baseline serum levels of neurofilament light (sNfL) and glial fibrillary acidic protein (sGFAP) were measured. The correlations between these biomarkers and neurological disability (Expanded Disability Status Scale, EDSS) and cognitive function (iPad-based processing speed test, PST) were analyzed at baseline and two years later. In this cohort of 41 NMOSD and 92 MS patients, blood biomarkers demonstrated distinct patterns of association with current and future outcomes. In NMOSD, sGFAP was consistently linked to neurological disability and cognitive impairment over time, reflecting astrocytopathy with minimal silent neurodegeneration. In MS, sGFAP did not correlate with baseline EDSS but showed associations with future scores. Notably, sNfL was more strongly associated with future PST scores than baseline scores (p = 0.005), suggesting ongoing neurodegeneration. These results underscore that blood biomarkers are predictive of both current and future outcomes in NMOSD and MS, with differing patterns reflecting the unique pathogenesis of each disease.https://doi.org/10.1038/s41598-025-95773-6Neuromyelitis Optica spectrum disorderMultiple sclerosisBiomarkersNeurofilament lightGlial fibrillary acidic protein |
| spellingShingle | Wangyong Shin Eun-Jae Lee Dayoung Seo Bum Joon Choi Inhye Jang Jin Hee Kim Lynkyung Choi Keonwoo Kim Ji-Yon Kim Hee-Jae Jung Hyemi Lee Hyunjin Kim Young-Min Lim Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis Scientific Reports Neuromyelitis Optica spectrum disorder Multiple sclerosis Biomarkers Neurofilament light Glial fibrillary acidic protein |
| title | Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis |
| title_full | Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis |
| title_fullStr | Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis |
| title_full_unstemmed | Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis |
| title_short | Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis |
| title_sort | distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis |
| topic | Neuromyelitis Optica spectrum disorder Multiple sclerosis Biomarkers Neurofilament light Glial fibrillary acidic protein |
| url | https://doi.org/10.1038/s41598-025-95773-6 |
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