Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study
AimTo assess through salivary biomarkers if clinical practices generate stress and a systemic inflammatory response in dental surgery post-graduate students.Materials and methodsA cross-sectional analytical observational study was conducted with students from the Master’s in Clinical Dentistry progr...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1568047/full |
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| author | Laura Barrientos-Moral Laura Barrientos-Moral María José Gimeno-Longas Cristina Obispo-Díaz Andrea Martín-Vacas Marta Macarena Paz-Cortés Marta Macarena Paz-Cortés Juan Manuel Aragoneses |
| author_facet | Laura Barrientos-Moral Laura Barrientos-Moral María José Gimeno-Longas Cristina Obispo-Díaz Andrea Martín-Vacas Marta Macarena Paz-Cortés Marta Macarena Paz-Cortés Juan Manuel Aragoneses |
| author_sort | Laura Barrientos-Moral |
| collection | DOAJ |
| description | AimTo assess through salivary biomarkers if clinical practices generate stress and a systemic inflammatory response in dental surgery post-graduate students.Materials and methodsA cross-sectional analytical observational study was conducted with students from the Master’s in Clinical Dentistry program. Salivary samples were collected before and after surgical procedures to quantify stress (cortisol) and inflammation biomarkers (IL-6, IL-1β, and CRP). Additionally, students completed the Perceived Stress Scale (PSS) questionnaire prior to the surgical procedure. Descriptive and analytic statistics were conducted with a 95% significance level.ResultsA total analyzed sample included 21 subjects, with a mean age of 25.5 years. The influence of academic year, gender, or smoking status was none found to have a significant impact. The results show a significant decrease in cortisol levels between the pre- and post-measurements (mean difference = −108.2 ± 166.7). However, an increase in IL-6 levels was obtained (p < 0.05). High IL-6 levels were associated with elevated CRP levels. An inverse relationship was seen between perceived stress and salivary cortisol concentrations.ConclusionThe findings show a significant decrease in salivary cortisol (stress) levels and a significant increase in salivary IL-6 levels following a dental implantology procedure in postgraduate oral surgery students. |
| format | Article |
| id | doaj-art-1d646c036e6c4bf983ce4a47e612c661 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-1d646c036e6c4bf983ce4a47e612c6612025-08-20T02:23:51ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.15680471568047Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot studyLaura Barrientos-Moral0Laura Barrientos-Moral1María José Gimeno-Longas2Cristina Obispo-Díaz3Andrea Martín-Vacas4Marta Macarena Paz-Cortés5Marta Macarena Paz-Cortés6Juan Manuel Aragoneses7Department of Systems Biology, Faculty of Medicine and Health Sciences, Universidad de Alcalá, Alcalá de Henares, SpainExperimental and Clinical Dentistry – Research Group, Facultad de Odontología, Universidad Alfonso X El Sabio, Villanueva de la Cañada, SpainDepartment of Cell Biology and Histology, School of Medicine, Universidad Complutense de Madrid, Madrid, SpainExperimental and Clinical Dentistry – Research Group, Facultad de Odontología, Universidad Alfonso X El Sabio, Villanueva de la Cañada, SpainExperimental and Clinical Dentistry – Research Group, Facultad de Odontología, Universidad Alfonso X El Sabio, Villanueva de la Cañada, SpainExperimental and Clinical Dentistry – Research Group, Facultad de Odontología, Universidad Alfonso X El Sabio, Villanueva de la Cañada, SpainClinical Specialties Department, Faculty of Dentistry. Universidad Complutense de Madrid, Madrid, SpainDepartment of Dental Research, Federico Henriquez y Carvajal University, Santo Domingo, Dominican RepublicAimTo assess through salivary biomarkers if clinical practices generate stress and a systemic inflammatory response in dental surgery post-graduate students.Materials and methodsA cross-sectional analytical observational study was conducted with students from the Master’s in Clinical Dentistry program. Salivary samples were collected before and after surgical procedures to quantify stress (cortisol) and inflammation biomarkers (IL-6, IL-1β, and CRP). Additionally, students completed the Perceived Stress Scale (PSS) questionnaire prior to the surgical procedure. Descriptive and analytic statistics were conducted with a 95% significance level.ResultsA total analyzed sample included 21 subjects, with a mean age of 25.5 years. The influence of academic year, gender, or smoking status was none found to have a significant impact. The results show a significant decrease in cortisol levels between the pre- and post-measurements (mean difference = −108.2 ± 166.7). However, an increase in IL-6 levels was obtained (p < 0.05). High IL-6 levels were associated with elevated CRP levels. An inverse relationship was seen between perceived stress and salivary cortisol concentrations.ConclusionThe findings show a significant decrease in salivary cortisol (stress) levels and a significant increase in salivary IL-6 levels following a dental implantology procedure in postgraduate oral surgery students.https://www.frontiersin.org/articles/10.3389/fmed.2025.1568047/fulldentistrydental educationoral surgeryinflammation mediatorsbiomarkers |
| spellingShingle | Laura Barrientos-Moral Laura Barrientos-Moral María José Gimeno-Longas Cristina Obispo-Díaz Andrea Martín-Vacas Marta Macarena Paz-Cortés Marta Macarena Paz-Cortés Juan Manuel Aragoneses Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study Frontiers in Medicine dentistry dental education oral surgery inflammation mediators biomarkers |
| title | Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study |
| title_full | Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study |
| title_fullStr | Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study |
| title_full_unstemmed | Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study |
| title_short | Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study |
| title_sort | analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students a pilot study |
| topic | dentistry dental education oral surgery inflammation mediators biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1568047/full |
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