Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors
In this study, we present a new, green electrochemical method for potentiometric estimation of desloratadine and montelukast sodium in their pure and binary dosage form. For that, three pencil graphite sensors were fabricated; the first one was prepared to analyse desloratadine drug (DES) by coating...
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Wiley
2021-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/5540907 |
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| author | Amir Alhaj Sakur Dania Nashed Imad Noureldin |
| author_facet | Amir Alhaj Sakur Dania Nashed Imad Noureldin |
| author_sort | Amir Alhaj Sakur |
| collection | DOAJ |
| description | In this study, we present a new, green electrochemical method for potentiometric estimation of desloratadine and montelukast sodium in their pure and binary dosage form. For that, three pencil graphite sensors were fabricated; the first one was prepared to analyse desloratadine drug (DES) by coating the graphite bar with the coating membrane, which comprises the ion pair of desloratadine and ammonium reineckate reagent (RNK), the polymer poly vinyl chloride (PVC), and the plasticizers dibutyl phthalate (DBP). The second one, which was used to analyse montelukast (MON), was constructed by using the ion pair of cadmium chloride reagent (Cd.) with montelukast and the same earlier named polymer and plasticizer. As a trial to analyse both of the drugs by the same sensor consecutively, we have constructed a combined pencil graphite electrode, which contains the two earlier suggested ion pairs, that is, we can use this electrode to selectively analyse for each drug. The proposed electrodes were effectively used for analysis of DES and MON as a single dosage form and as combined pharmaceutical preparation, without any need for prior separation that was performed depending on the difference in the efficient pH range for each sensor. The proposed sensors exhibited a Nernstian equation slopes of −30.11, 27.70, (−29.16, 29.79) mv. decade−1 in the linearity range 5.00 × 10−5−1.00 × 10−2 and 1.00 × 10−5 − 1.00 × 10−2 M, respectively. The sensors exhibit high sensitivity according to LOD values ((0.036–0.018) − (0.025-0.026) µM), respectively, and important selectivity toward the studied drugs in presence of interfering ions and excipients. The optimum circumstances were studied, and the method was validated by application of ICH rules. Finally, the method was compared with a documented method, and the required statistical values were calculated. |
| format | Article |
| id | doaj-art-1d63b261d0094e73a8e602c932995362 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-1d63b261d0094e73a8e602c9329953622025-08-20T03:54:37ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732021-01-01202110.1155/2021/55409075540907Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical SensorsAmir Alhaj Sakur0Dania Nashed1Imad Noureldin2Analytical and Food Chemistry Department, Faculty of Pharmacy Aleppo University, Aleppo, SyriaAnalytical and Food Chemistry Department, Faculty of Pharmacy Aleppo University, Aleppo, SyriaAnalytical and Food Chemistry Department, Faculty of Pharmacy Aleppo University, Aleppo, SyriaIn this study, we present a new, green electrochemical method for potentiometric estimation of desloratadine and montelukast sodium in their pure and binary dosage form. For that, three pencil graphite sensors were fabricated; the first one was prepared to analyse desloratadine drug (DES) by coating the graphite bar with the coating membrane, which comprises the ion pair of desloratadine and ammonium reineckate reagent (RNK), the polymer poly vinyl chloride (PVC), and the plasticizers dibutyl phthalate (DBP). The second one, which was used to analyse montelukast (MON), was constructed by using the ion pair of cadmium chloride reagent (Cd.) with montelukast and the same earlier named polymer and plasticizer. As a trial to analyse both of the drugs by the same sensor consecutively, we have constructed a combined pencil graphite electrode, which contains the two earlier suggested ion pairs, that is, we can use this electrode to selectively analyse for each drug. The proposed electrodes were effectively used for analysis of DES and MON as a single dosage form and as combined pharmaceutical preparation, without any need for prior separation that was performed depending on the difference in the efficient pH range for each sensor. The proposed sensors exhibited a Nernstian equation slopes of −30.11, 27.70, (−29.16, 29.79) mv. decade−1 in the linearity range 5.00 × 10−5−1.00 × 10−2 and 1.00 × 10−5 − 1.00 × 10−2 M, respectively. The sensors exhibit high sensitivity according to LOD values ((0.036–0.018) − (0.025-0.026) µM), respectively, and important selectivity toward the studied drugs in presence of interfering ions and excipients. The optimum circumstances were studied, and the method was validated by application of ICH rules. Finally, the method was compared with a documented method, and the required statistical values were calculated.http://dx.doi.org/10.1155/2021/5540907 |
| spellingShingle | Amir Alhaj Sakur Dania Nashed Imad Noureldin Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors Journal of Analytical Methods in Chemistry |
| title | Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors |
| title_full | Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors |
| title_fullStr | Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors |
| title_full_unstemmed | Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors |
| title_short | Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors |
| title_sort | selective consecutive determination of desloratadine and montelukast sodium in their pure and binary dosage form based on pencil graphite electrochemical sensors |
| url | http://dx.doi.org/10.1155/2021/5540907 |
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