The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses

The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses

IntroductionIn 2015, the FDA released a Drug Safety Communication regarding a possible link between opioid exposure during early pregnancy and an increased risk of fetal neural tube defects (NTDs). At the time, the indications for opioid use during pregnancy were not changed due to incomplete matern...

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Bibliographic Details
Main Authors: Dustyn Barnette, Amy L. Inselman, Pravin Kaldhone, Grace S. Lee, Kelly Davis, Sumit Sarkar, Pritpal Malhi, J. Edward Fisher, Joseph P. Hanig, Richard D. Beger, E. Ellen Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Toxicology
Subjects:
morphine
exencephaly
opioid
MALDI MSI
lipids
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2024.1452974/full
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