Sustained Endocytosis Inhibition via Locally‐Injected Drug‐Eluting Hydrogel Improves ADCC‐Mediated Antibody Therapy in Colorectal Cancer

Sustained Endocytosis Inhibition via Locally‐Injected Drug‐Eluting Hydrogel Improves ADCC‐Mediated Antibody Therapy in Colorectal Cancer

Abstract The epidermal growth factor receptor (EGFR) is a validated therapeutic target for RAS/RAF wild‐type colorectal cancer (CRC). However, monoclonal antibody‐based anti‐EGFR therapies such as cetuximab have limited effectiveness. Herein, it is identified that EGFR internalization is associated...

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Bibliographic Details
Main Authors: Chong Wu, Xiaoting Liu, Rong Liu, Shiyao Song, Zi‐Fan Zheng, Yilin Zeng, Yong Mei, Jing‐Yang Zhang, Qijia Duan, Run Lin, Jin‐Zhi Du, Weiling He
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
antibody‐dependent cell‐mediated cytotoxicity
colorectal cancer
endocytosis inhibition
epidermal growth factor receptor
hydrogel
targeted therapy
Online Access:https://doi.org/10.1002/advs.202407239
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