The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse

The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse

Background Pelvic organ prolapse (POP), characterised by the downward displacement of pelvic organs, is a prevalent disorder that affects adult women. This study explored the therapeutic potential of PX-478, a selective hypoxia-inducible factor-1α (HIF-1α) inhibitor, in a murine POP model.Methods A...

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Bibliographic Details
Main Authors: Wei-Min Fan, Yu-Qi Yang, Li-Wen Zhang, Xiao-Hui Mei, Ke Sun, Duan-Qing Wu, Ying Yang, Chun-Fang Duan, Jun Ye, Ru-Jun Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Obstetrics and Gynaecology
Subjects:
Pelvic organ prolapse (POP)
fibroblasts
hypoxia-inducible factor-1α (HIF-1α)
PX-478
macrophages
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/01443615.2024.2415669
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