Imaging Multidimensional Therapeutically Relevant Circadian Relationships
Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous proliferating tissues. The timing within the circadian cycle of the administration of drugs targeting...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2009/231539 |
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| author | Jamil Singletary Patricia A. Wood Jovelyn Du-Quiton Song Wang Xiaoming Yang Shobhit Vishnoi William J. M. Hrushesky |
| author_facet | Jamil Singletary Patricia A. Wood Jovelyn Du-Quiton Song Wang Xiaoming Yang Shobhit Vishnoi William J. M. Hrushesky |
| author_sort | Jamil Singletary |
| collection | DOAJ |
| description | Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous proliferating tissues. The timing within the circadian cycle of the administration of drugs targeting proliferative pathways necessarily impacts the amount of damage done to proliferating tissues and cancers. Concurrently measuring target levels and associated key pathway components in normal and malignant tissues around the circadian clock provides a path toward a fuller understanding of the temporal relationships among the physiologic processes governing the therapeutic index of antiproliferative anticancer therapies. The temporal ordering among these relationships, paramount to determining causation, is less well understood using two- or three-dimensional representations. We have created multidimensional multimedia depictions of the temporal unfolding of putatively causative and the resultant therapeutic effects of a drug that specifically targets these ordered processes at specific times of the day. The systems and methods used to create these depictions are provided, as well as three example supplementary movies. |
| format | Article |
| id | doaj-art-1d5939f4432140e593c31e43bfe8fc3f |
| institution | OA Journals |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-1d5939f4432140e593c31e43bfe8fc3f2025-08-20T02:01:39ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962009-01-01200910.1155/2009/231539231539Imaging Multidimensional Therapeutically Relevant Circadian RelationshipsJamil Singletary0Patricia A. Wood1Jovelyn Du-Quiton2Song Wang3Xiaoming Yang4Shobhit Vishnoi5William J. M. Hrushesky6Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USAMedical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USAMedical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USACollege of Engineering and Computing, University of South Carolina, SC 29209, USAMedical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USAMedical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USAMedical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USACircadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous proliferating tissues. The timing within the circadian cycle of the administration of drugs targeting proliferative pathways necessarily impacts the amount of damage done to proliferating tissues and cancers. Concurrently measuring target levels and associated key pathway components in normal and malignant tissues around the circadian clock provides a path toward a fuller understanding of the temporal relationships among the physiologic processes governing the therapeutic index of antiproliferative anticancer therapies. The temporal ordering among these relationships, paramount to determining causation, is less well understood using two- or three-dimensional representations. We have created multidimensional multimedia depictions of the temporal unfolding of putatively causative and the resultant therapeutic effects of a drug that specifically targets these ordered processes at specific times of the day. The systems and methods used to create these depictions are provided, as well as three example supplementary movies.http://dx.doi.org/10.1155/2009/231539 |
| spellingShingle | Jamil Singletary Patricia A. Wood Jovelyn Du-Quiton Song Wang Xiaoming Yang Shobhit Vishnoi William J. M. Hrushesky Imaging Multidimensional Therapeutically Relevant Circadian Relationships International Journal of Biomedical Imaging |
| title | Imaging Multidimensional Therapeutically Relevant Circadian Relationships |
| title_full | Imaging Multidimensional Therapeutically Relevant Circadian Relationships |
| title_fullStr | Imaging Multidimensional Therapeutically Relevant Circadian Relationships |
| title_full_unstemmed | Imaging Multidimensional Therapeutically Relevant Circadian Relationships |
| title_short | Imaging Multidimensional Therapeutically Relevant Circadian Relationships |
| title_sort | imaging multidimensional therapeutically relevant circadian relationships |
| url | http://dx.doi.org/10.1155/2009/231539 |
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