Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy
Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson’s disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age-...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/9730319 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567635551715328 |
|---|---|
| author | Ruwei Ou Wei Song Qianqian Wei Ke Chen Bei Cao Yanbing Hou Bi Zhao Huifang Shang |
| author_facet | Ruwei Ou Wei Song Qianqian Wei Ke Chen Bei Cao Yanbing Hou Bi Zhao Huifang Shang |
| author_sort | Ruwei Ou |
| collection | DOAJ |
| description | Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson’s disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of “sleep/fatigue,” “mood/apathy,” “attention/memory,” “gastrointestinal,” “sexual dysfunction,” and “miscellaneous” domains in PSP group were significantly higher than those in HC group (P<0.05). The frequency of “mood/apathy,” “attention/memory,” and “sexual dysfunction” domains and the severity of “attention/memory” and “gastrointestinal” domains in PSP group were significantly higher than those in PD group (P<0.05). The “attention/memory” domain in PSP had a significant but weak-to-moderate correlation with age (R=0.387, P=0.046) and onset age (R=0.406, P=0.036). Conclusions. NMS are common in PSP patients. Patients with PSP seem to be subjected to more frequent and severe specific NMS compared to healthy aging subjects and PD patients. Older PSP patients and late-onset patients are likely to be subjected to cognitive decline. |
| format | Article |
| id | doaj-art-1d52b7ac19474da5942b9664f5c32258 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-1d52b7ac19474da5942b9664f5c322582025-02-03T01:00:57ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/97303199730319Characteristics of Nonmotor Symptoms in Progressive Supranuclear PalsyRuwei Ou0Wei Song1Qianqian Wei2Ke Chen3Bei Cao4Yanbing Hou5Bi Zhao6Huifang Shang7Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaObjectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson’s disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of “sleep/fatigue,” “mood/apathy,” “attention/memory,” “gastrointestinal,” “sexual dysfunction,” and “miscellaneous” domains in PSP group were significantly higher than those in HC group (P<0.05). The frequency of “mood/apathy,” “attention/memory,” and “sexual dysfunction” domains and the severity of “attention/memory” and “gastrointestinal” domains in PSP group were significantly higher than those in PD group (P<0.05). The “attention/memory” domain in PSP had a significant but weak-to-moderate correlation with age (R=0.387, P=0.046) and onset age (R=0.406, P=0.036). Conclusions. NMS are common in PSP patients. Patients with PSP seem to be subjected to more frequent and severe specific NMS compared to healthy aging subjects and PD patients. Older PSP patients and late-onset patients are likely to be subjected to cognitive decline.http://dx.doi.org/10.1155/2016/9730319 |
| spellingShingle | Ruwei Ou Wei Song Qianqian Wei Ke Chen Bei Cao Yanbing Hou Bi Zhao Huifang Shang Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy Parkinson's Disease |
| title | Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy |
| title_full | Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy |
| title_fullStr | Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy |
| title_full_unstemmed | Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy |
| title_short | Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy |
| title_sort | characteristics of nonmotor symptoms in progressive supranuclear palsy |
| url | http://dx.doi.org/10.1155/2016/9730319 |
| work_keys_str_mv | AT ruweiou characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT weisong characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT qianqianwei characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT kechen characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT beicao characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT yanbinghou characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT bizhao characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy AT huifangshang characteristicsofnonmotorsymptomsinprogressivesupranuclearpalsy |