IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment

IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment

Abstract Background Glioblastoma multiforme (GBM) is an aggressive brain tumor with chemoresistant, immunosuppressive, and invasive properties. Despite standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, tumors inevitably recur in the peritumoral region. Targeti...

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Main Authors: Gilbert Aaron Lee, Justin Bo-Kai Hsu, Yu-Wei Chang, Li-Chun Hsieh, Yi-Tien Li, Ying Chieh Wu, Cheng-Ying Chu, Yung-Hsiao Chiang, Wan-Yuo Guo, Chih-Chun Wu, Liang-Wei Chen, Hung-Wen Kao, Wan-Li Lin, Li‑Wen Tseng, Ting-Wei Weng, Duen-Pang Kuo, Sho-Jen Cheng, Yung-Chieh Chen, Shiu-Wen Huang, Hsing-Jien Kung, Cheng-Yu Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Biomedical Science
Subjects:
IL-19
Glioblastoma
Temozolomide
Online Access:https://doi.org/10.1186/s12929-025-01126-w
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