Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues
Abstract Image-based modeling heavily relies on boundary conditions to obtain realistic blood flow and pressure. For the cerebrovascular system, boundary conditions are derived using in-vivo measurements or geometry-based models such as Murray’s law, but these are constrained by the image resolution...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-10223-7 |
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| author | Chang Min Lee Hans Christian Rundfeldt Keun-Hwa Jung Hyeyeon Chang Hyun Jin Kim |
| author_facet | Chang Min Lee Hans Christian Rundfeldt Keun-Hwa Jung Hyeyeon Chang Hyun Jin Kim |
| author_sort | Chang Min Lee |
| collection | DOAJ |
| description | Abstract Image-based modeling heavily relies on boundary conditions to obtain realistic blood flow and pressure. For the cerebrovascular system, boundary conditions are derived using in-vivo measurements or geometry-based models such as Murray’s law, but these are constrained by the image resolution or high sensitivity to the segmented geometry. We propose a physiologic model of the cerebrovascular system based on a supply and demand relationship between arteries and tissues. Blood flow and perfusion territory are determined by associating brain tissues with nearby vessels using Voronoi tessellation. The model was evaluated for 40 healthy young individuals and two diseased patients, and was validated by comparing the estimated blood flows and perfusion territories against literature data and perfusion imaging. The estimated blood flows are within the physiologically reported values for major cerebral arteries and the predicted perfusion territories are similar to the literature and perfusion imaging. Further, the model demonstrates more robustness to segmentation uncertainties compared to Murray’s law. The proposed model is shown to estimate physiologically plausible cerebrovascular blood flow and perfusion territory in a subject-specific manner using medical image data only. It may be used to simulate blood flow more realistically by developing boundary conditions based on this model in the cerebrovascular system. |
| format | Article |
| id | doaj-art-1d3f267738cb4e7782d6711b25b89381 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1d3f267738cb4e7782d6711b25b893812025-08-20T03:05:25ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-10223-7Physiologic model of the cerebrovascular system using supply and demand between arteries and tissuesChang Min Lee0Hans Christian Rundfeldt1Keun-Hwa Jung2Hyeyeon Chang3Hyun Jin Kim4Department of Mechanical Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Mechanical Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Neurology, Seoul National University HospitalDepartment of Neurology, Konyang University HospitalDepartment of Mechanical Engineering, Korea Advanced Institute of Science and TechnologyAbstract Image-based modeling heavily relies on boundary conditions to obtain realistic blood flow and pressure. For the cerebrovascular system, boundary conditions are derived using in-vivo measurements or geometry-based models such as Murray’s law, but these are constrained by the image resolution or high sensitivity to the segmented geometry. We propose a physiologic model of the cerebrovascular system based on a supply and demand relationship between arteries and tissues. Blood flow and perfusion territory are determined by associating brain tissues with nearby vessels using Voronoi tessellation. The model was evaluated for 40 healthy young individuals and two diseased patients, and was validated by comparing the estimated blood flows and perfusion territories against literature data and perfusion imaging. The estimated blood flows are within the physiologically reported values for major cerebral arteries and the predicted perfusion territories are similar to the literature and perfusion imaging. Further, the model demonstrates more robustness to segmentation uncertainties compared to Murray’s law. The proposed model is shown to estimate physiologically plausible cerebrovascular blood flow and perfusion territory in a subject-specific manner using medical image data only. It may be used to simulate blood flow more realistically by developing boundary conditions based on this model in the cerebrovascular system.https://doi.org/10.1038/s41598-025-10223-7Physiologic modelCerebrovascular systemSupply and demand relationshipPerfusion territoryBlood flow Estimation of cerebral arteriesBoundary condition |
| spellingShingle | Chang Min Lee Hans Christian Rundfeldt Keun-Hwa Jung Hyeyeon Chang Hyun Jin Kim Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues Scientific Reports Physiologic model Cerebrovascular system Supply and demand relationship Perfusion territory Blood flow Estimation of cerebral arteries Boundary condition |
| title | Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues |
| title_full | Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues |
| title_fullStr | Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues |
| title_full_unstemmed | Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues |
| title_short | Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues |
| title_sort | physiologic model of the cerebrovascular system using supply and demand between arteries and tissues |
| topic | Physiologic model Cerebrovascular system Supply and demand relationship Perfusion territory Blood flow Estimation of cerebral arteries Boundary condition |
| url | https://doi.org/10.1038/s41598-025-10223-7 |
| work_keys_str_mv | AT changminlee physiologicmodelofthecerebrovascularsystemusingsupplyanddemandbetweenarteriesandtissues AT hanschristianrundfeldt physiologicmodelofthecerebrovascularsystemusingsupplyanddemandbetweenarteriesandtissues AT keunhwajung physiologicmodelofthecerebrovascularsystemusingsupplyanddemandbetweenarteriesandtissues AT hyeyeonchang physiologicmodelofthecerebrovascularsystemusingsupplyanddemandbetweenarteriesandtissues AT hyunjinkim physiologicmodelofthecerebrovascularsystemusingsupplyanddemandbetweenarteriesandtissues |