Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy
Prevention of brain injury during carotid endarterectomy (CEA) remains a significant challenge. Moderate controlled systemic hypothermia may serve as a potential neuroprotective measure during these procedures.Aim of the study. To investigate the neuroprotective effects of moderate systemic hypother...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2025-02-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/2502 |
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| author | Alexey A. Syrovatsky Ionas S. Simutis Alexey V. Svetlikov Konstantin M. Lebedinsky Alexey N. Shcheglov Vyacheslav A. Ratnikov Daria E. Reznichek Evgenia V. Khaldina |
| author_facet | Alexey A. Syrovatsky Ionas S. Simutis Alexey V. Svetlikov Konstantin M. Lebedinsky Alexey N. Shcheglov Vyacheslav A. Ratnikov Daria E. Reznichek Evgenia V. Khaldina |
| author_sort | Alexey A. Syrovatsky |
| collection | DOAJ |
| description | Prevention of brain injury during carotid endarterectomy (CEA) remains a significant challenge. Moderate controlled systemic hypothermia may serve as a potential neuroprotective measure during these procedures.Aim of the study. To investigate the neuroprotective effects of moderate systemic hypothermia during CEA.Materials and methods. Fifty-nine patients undergoing CEA under combined anesthesia were included. Patients were divided into two groups: the hypothermia group (N=33) and the normothermia control group (N=26). Both groups received standard measures to prevent cerebral ischemia. The hypothermia group received additional moderate systemic hypothermia aimed at a temperature range of 34–35°C. Cognitive function was assessed preoperatively and at 2, 5, and 30 days postoperatively using neurocognitive tests. Statistical analysis was performed with IBM SPSS Statistics.Results. The incidence of cognitive impairment was 21.1% in the hypothermia group and 26.9% in the normothermia group. Postoperative cognitive impairment was more common in the normothermia group: 15.38% on day 5 and 11.5% on day 30 postoperatively compared to 12.1% and 6.1% in the hypothermia group (P<0.05).Conclusion. This study demonstrated the neuroprotective effects of hypothermia, manifested by a reduced severity of cognitive impairment in the hypothermia group. Further research is needed to identify high-risk patients who would benefit most from this neuroprotective strategy and to optimize hypothermia protocols. |
| format | Article |
| id | doaj-art-1d3e87b61daf46cfaf58b0eb791e255f |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-1d3e87b61daf46cfaf58b0eb791e255f2025-08-20T02:59:35ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102025-02-01211283710.15360/1813-9779-2025-1-28-371986Perioperative Neuroprotection with Systemic Hypothermia During Carotid EndarterectomyAlexey A. Syrovatsky0Ionas S. Simutis1Alexey V. Svetlikov2Konstantin M. Lebedinsky3Alexey N. Shcheglov4Vyacheslav A. Ratnikov5Daria E. Reznichek6Evgenia V. Khaldina7Sokolov Northwestern District Research and Clinical Center, Federal Medico-Biological Agency of RussiaSokolov Northwestern District Research and Clinical Center, Federal Medico-Biological Agency of Russia; I. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaSokolov Northwestern District Research and Clinical Center, Federal Medico-Biological Agency of Russia; St. Petersburg State UniversityI. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia; Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyCentral Clinical Hospital with Outpatient, Russian Presidential Administration DepartmentSokolov Northwestern District Research and Clinical Center, Federal Medico-Biological Agency of RussiaI. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaPrevention of brain injury during carotid endarterectomy (CEA) remains a significant challenge. Moderate controlled systemic hypothermia may serve as a potential neuroprotective measure during these procedures.Aim of the study. To investigate the neuroprotective effects of moderate systemic hypothermia during CEA.Materials and methods. Fifty-nine patients undergoing CEA under combined anesthesia were included. Patients were divided into two groups: the hypothermia group (N=33) and the normothermia control group (N=26). Both groups received standard measures to prevent cerebral ischemia. The hypothermia group received additional moderate systemic hypothermia aimed at a temperature range of 34–35°C. Cognitive function was assessed preoperatively and at 2, 5, and 30 days postoperatively using neurocognitive tests. Statistical analysis was performed with IBM SPSS Statistics.Results. The incidence of cognitive impairment was 21.1% in the hypothermia group and 26.9% in the normothermia group. Postoperative cognitive impairment was more common in the normothermia group: 15.38% on day 5 and 11.5% on day 30 postoperatively compared to 12.1% and 6.1% in the hypothermia group (P<0.05).Conclusion. This study demonstrated the neuroprotective effects of hypothermia, manifested by a reduced severity of cognitive impairment in the hypothermia group. Further research is needed to identify high-risk patients who would benefit most from this neuroprotective strategy and to optimize hypothermia protocols.https://www.reanimatology.com/rmt/article/view/2502neuroprotection by systemic hypothermiatherapeutic hypothermiamoderate hypothermiacarotid endarterectomy |
| spellingShingle | Alexey A. Syrovatsky Ionas S. Simutis Alexey V. Svetlikov Konstantin M. Lebedinsky Alexey N. Shcheglov Vyacheslav A. Ratnikov Daria E. Reznichek Evgenia V. Khaldina Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy Общая реаниматология neuroprotection by systemic hypothermia therapeutic hypothermia moderate hypothermia carotid endarterectomy |
| title | Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy |
| title_full | Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy |
| title_fullStr | Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy |
| title_full_unstemmed | Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy |
| title_short | Perioperative Neuroprotection with Systemic Hypothermia During Carotid Endarterectomy |
| title_sort | perioperative neuroprotection with systemic hypothermia during carotid endarterectomy |
| topic | neuroprotection by systemic hypothermia therapeutic hypothermia moderate hypothermia carotid endarterectomy |
| url | https://www.reanimatology.com/rmt/article/view/2502 |
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