Evolution of Mycobacterium abscessus in the human lung: Cumulative mutations and genomic rearrangement of porin genes in patient isolates

Evolution of Mycobacterium abscessus in the human lung: Cumulative mutations and genomic rearrangement of porin genes in patient isolates

Background Mycobacterium abscessus subspecies massiliense (M. massiliense) is increasingly recognized as an emerging bacterial pathogen, particularly in cystic fibrosis (CF) patients and CF centres’ respiratory outbreaks. We characterized genomic and phenotypic changes in 15 serial isolates from two...

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Main Authors: Shamira J. Shallom, Hervé Tettelin, Prabha Chandrasekaran, In Kwon Park, Sonia Agrawal, Kriti Arora, Lisa Sadzewicz, Aaron M. Milstone, Moira L. Aitken, Barbara A. Brown-Elliott, Richard J. Wallace, Elizabeth P. Sampaio, Michael Niederweis, Kenneth N. Olivier, Steven M. Holland, Adrian M. Zelazny
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Virulence
Subjects:
Mycobacterium massiliense
Mycobacterium abscessus
cystic fibrosis
Porin
whole genome sequencing
immune response
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2023.2215602
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