CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives
Introduction: Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment, showing significant success in hematologic malignancies. However, its application in solid tumors like gastrointestinal (GI) and head and neck cancers, as well as autoimmune diseases, remains a challen...
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Kazimierz Wielki University
2025-05-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/59839 |
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| author | Martyna Kania Hanna Bartkowiak Damian Grubski Agnieszka Adamowska Filip Nadolny Julia Janecka Jędrzej Jabłoński Alicja Śniatała Michał Hofman Adam Dudek |
| author_facet | Martyna Kania Hanna Bartkowiak Damian Grubski Agnieszka Adamowska Filip Nadolny Julia Janecka Jędrzej Jabłoński Alicja Śniatała Michał Hofman Adam Dudek |
| author_sort | Martyna Kania |
| collection | DOAJ |
| description |
Introduction: Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment, showing significant success in hematologic malignancies. However, its application in solid tumors like gastrointestinal (GI) and head and neck cancers, as well as autoimmune diseases, remains a challenge. The development of CAR-T cell therapy for these indications presents unique difficulties, including tumor heterogeneity, antigen specificity, and immune suppression within the tumor microenvironment.
Aim of the study: This review aims to provide an in-depth analysis of the current advancements in CAR-T cell therapy for gastrointestinal cancer, head and neck cancer, and autoimmune diseases. We seek to evaluate the therapeutic potential, current challenges, and future directions of CAR-T cell-based interventions in these conditions.
Materials and methods: We performed a comprehensive literature review, analyzing recent clinical trials, preclinical studies, and research published in PubMed and Google Scholar. We focused on CAR-T cell therapy targeting solid tumors and autoimmune diseases, current treatment options, clinical efficacy, and safety concerns across these therapeutic areas.
Conclusions: CAR-T cell therapy has shown promising potential in the treatment of gastrointestinal cancers, head and neck cancers, and autoimmune diseases, but its clinical application remains limited by challenges such as antigen escape, off-tumor toxicity, and insufficient T-cell persistence. Future studies must focus on improving CAR design, enhancing targeting accuracy, and addressing the immunosuppressive tumor environment to unlock the full therapeutic potential of CAR-T cells for these indications.
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| format | Article |
| id | doaj-art-1d3e1b6c50b44e9595936314a26f6aa5 |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-1d3e1b6c50b44e9595936314a26f6aa52025-08-20T02:15:12ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-05-018110.12775/JEHS.2025.81.59839CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future PerspectivesMartyna Kania0https://orcid.org/0009-0006-4400-0258Hanna Bartkowiak 1https://orcid.org/0009-0000-6914-4908Damian Grubski2https://orcid.org/0009-0003-9501-9950Agnieszka Adamowska3https://orcid.org/0009-0009-1977-2522Filip Nadolny4https://orcid.org/0009-0000-6433-5975Julia Janecka5https://orcid.org/0009-0005-9011-817XJędrzej Jabłoński6https://orcid.org/0009-0009-6204-407XAlicja Śniatała7https://orcid.org/0009-0003-8488-3268Michał Hofman8https://orcid.org/0000-0001-9365-4537Adam Dudek9https://orcid.org/0009-0001-3373-2625University Hospital in PoznanJózef Struś Multispecialist Muncipal Hospital Szwajcarska 3, 61-285 Poznań Józef Struś Multispecialist Municipal Hospital Szwajcarska 3, 61-285 PoznańJózef Struś Multispecialist Muncipal Hospital; Szwajcarska 3, 61-285 PoznańUniversity Hospital in Poznań Przybyszewskiego 49, 60-355 Poznań University Hospital in Poznań Przybyszewskiego 49, 60-355 Poznań Regional Hospital in Poznań, Juraszów 7-19, 60-479 PoznańRegional Hospital in Poznań, Juraszów 7-19, 60-479 PoznańMedical Center HCP 28 czerwca 1956 r. nr 194, 61-485 PoznańUniversity Hospital in Poznań Przybyszewskiego 49, 60-355 Poznań Introduction: Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment, showing significant success in hematologic malignancies. However, its application in solid tumors like gastrointestinal (GI) and head and neck cancers, as well as autoimmune diseases, remains a challenge. The development of CAR-T cell therapy for these indications presents unique difficulties, including tumor heterogeneity, antigen specificity, and immune suppression within the tumor microenvironment. Aim of the study: This review aims to provide an in-depth analysis of the current advancements in CAR-T cell therapy for gastrointestinal cancer, head and neck cancer, and autoimmune diseases. We seek to evaluate the therapeutic potential, current challenges, and future directions of CAR-T cell-based interventions in these conditions. Materials and methods: We performed a comprehensive literature review, analyzing recent clinical trials, preclinical studies, and research published in PubMed and Google Scholar. We focused on CAR-T cell therapy targeting solid tumors and autoimmune diseases, current treatment options, clinical efficacy, and safety concerns across these therapeutic areas. Conclusions: CAR-T cell therapy has shown promising potential in the treatment of gastrointestinal cancers, head and neck cancers, and autoimmune diseases, but its clinical application remains limited by challenges such as antigen escape, off-tumor toxicity, and insufficient T-cell persistence. Future studies must focus on improving CAR design, enhancing targeting accuracy, and addressing the immunosuppressive tumor environment to unlock the full therapeutic potential of CAR-T cells for these indications. https://apcz.umk.pl/JEHS/article/view/59839CAR-TChimeric Antigen ReceptorHead and Neck CancerSystemic Lupus ErythematosusImmunotherapyGastrointestinal tumors |
| spellingShingle | Martyna Kania Hanna Bartkowiak Damian Grubski Agnieszka Adamowska Filip Nadolny Julia Janecka Jędrzej Jabłoński Alicja Śniatała Michał Hofman Adam Dudek CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives Journal of Education, Health and Sport CAR-T Chimeric Antigen Receptor Head and Neck Cancer Systemic Lupus Erythematosus Immunotherapy Gastrointestinal tumors |
| title | CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives |
| title_full | CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives |
| title_fullStr | CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives |
| title_full_unstemmed | CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives |
| title_short | CAR-T Cell Therapy in Gastrointestinal Cancer, Head and Neck Cancer, and Autoimmune Diseases: Current Advances and Future Perspectives |
| title_sort | car t cell therapy in gastrointestinal cancer head and neck cancer and autoimmune diseases current advances and future perspectives |
| topic | CAR-T Chimeric Antigen Receptor Head and Neck Cancer Systemic Lupus Erythematosus Immunotherapy Gastrointestinal tumors |
| url | https://apcz.umk.pl/JEHS/article/view/59839 |
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