Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus
Freezing of gait (FOG) is a common disorder in Parkinson’s disease (PD) and could be attributed to a reduction in brain noradrenaline. The aim of this study was to determine the relationship between aromatic L-amino acid decarboxylase (AADC) activity in the locus coeruleus (LC) and FOG in PD using h...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/5430920 |
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| author | Sayaka Asari Ono Toshihiko Sato Shin-ichi Muramatsu |
| author_facet | Sayaka Asari Ono Toshihiko Sato Shin-ichi Muramatsu |
| author_sort | Sayaka Asari Ono |
| collection | DOAJ |
| description | Freezing of gait (FOG) is a common disorder in Parkinson’s disease (PD) and could be attributed to a reduction in brain noradrenaline. The aim of this study was to determine the relationship between aromatic L-amino acid decarboxylase (AADC) activity in the locus coeruleus (LC) and FOG in PD using high-resolution positron emission tomography with an AADC tracer, 6-[18F]fluoro-L-m-tyrosine (FMT). We assessed 40 patients with PD and 11 age-matched healthy individuals. PD was diagnosed based on the UK Brain Bank criteria by two movement disorder experts. FOG was directly observed by the clinician and assessed using a patient questionnaire. FMT uptake in the LC, caudate, and putamen was analyzed using PMOD software on coregistered magnetic resonance images. FOG was present in 30 patients. The severity of FOG correlated with the decrease of FMT uptake in the LC regardless of disease duration and the severity of other motor impairments, indicating dysfunction of the noradrenergic network in FOG. |
| format | Article |
| id | doaj-art-1d3af4eb230b45cfa38dff3052f2e860 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-1d3af4eb230b45cfa38dff3052f2e8602025-08-20T03:54:51ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/54309205430920Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus CoeruleusSayaka Asari Ono0Toshihiko Sato1Shin-ichi Muramatsu2Division of Neurology, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, JapanUtsunomiya Central Clinic, Tochigi 321-0112, JapanDivision of Neurology, Jichi Medical University, Tochigi 329-0498, JapanFreezing of gait (FOG) is a common disorder in Parkinson’s disease (PD) and could be attributed to a reduction in brain noradrenaline. The aim of this study was to determine the relationship between aromatic L-amino acid decarboxylase (AADC) activity in the locus coeruleus (LC) and FOG in PD using high-resolution positron emission tomography with an AADC tracer, 6-[18F]fluoro-L-m-tyrosine (FMT). We assessed 40 patients with PD and 11 age-matched healthy individuals. PD was diagnosed based on the UK Brain Bank criteria by two movement disorder experts. FOG was directly observed by the clinician and assessed using a patient questionnaire. FMT uptake in the LC, caudate, and putamen was analyzed using PMOD software on coregistered magnetic resonance images. FOG was present in 30 patients. The severity of FOG correlated with the decrease of FMT uptake in the LC regardless of disease duration and the severity of other motor impairments, indicating dysfunction of the noradrenergic network in FOG.http://dx.doi.org/10.1155/2016/5430920 |
| spellingShingle | Sayaka Asari Ono Toshihiko Sato Shin-ichi Muramatsu Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus Parkinson's Disease |
| title | Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus |
| title_full | Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus |
| title_fullStr | Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus |
| title_full_unstemmed | Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus |
| title_short | Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-L-m-tyrosine Uptake in the Locus Coeruleus |
| title_sort | freezing of gait in parkinson s disease is associated with reduced 6 18f fluoro l m tyrosine uptake in the locus coeruleus |
| url | http://dx.doi.org/10.1155/2016/5430920 |
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