Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis
IntroductionThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473895/full |
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| author | Sunho Lee Sunho Lee Jueun Lee Kwang-Soo Lyoo Yourim Shin Yourim Shin Dong-Min Shin Jun-Won Kim Jeong-Sun Yang Kyung-Chang Kim Joo-Yeon Lee Geum-Sook Hwang Geum-Sook Hwang |
| author_facet | Sunho Lee Sunho Lee Jueun Lee Kwang-Soo Lyoo Yourim Shin Yourim Shin Dong-Min Shin Jun-Won Kim Jeong-Sun Yang Kyung-Chang Kim Joo-Yeon Lee Geum-Sook Hwang Geum-Sook Hwang |
| author_sort | Sunho Lee |
| collection | DOAJ |
| description | IntroductionThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune responses and metabolism induced by these variants. MethodsHere, metabolomics combined with transcriptomics was performed to elucidate the immunometabolic changes in the lung of hamsters infected with delta and omicron variants.ResultsBoth variants caused acute inflammation and lung pathology in intranasally infected hamsters. Principal component analysis uncovered the delta variant significantly altered lung metabolite levels between the pre- and post-infection states. Additionally, metabolic pathways determined by assessment of metabolites and genes in lung revealed significant alterations in arginine biosynthesis, glutathione metabolism, and tryptophan metabolism upon infection with both variants and closely linked to inflammatory cytokines, indicating immune activation and oxidative stress in response to both variants. These metabolic changes were also evident in the serum, validating the presence of systemic alterations corresponding to those identified in lung. Notably, the delta variant induced a more robust metabolic regulation than the omicron variant. DiscussionThe study suggests that multi-omics is a valuable approach for understanding immunometabolic responses to infectious diseases, and providing insights for effective treatment strategies. |
| format | Article |
| id | doaj-art-1d2cf9cff9d64500a8aeafe8c10ba2de |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1d2cf9cff9d64500a8aeafe8c10ba2de2025-08-20T01:47:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14738951473895Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysisSunho Lee0Sunho Lee1Jueun Lee2Kwang-Soo Lyoo3Yourim Shin4Yourim Shin5Dong-Min Shin6Jun-Won Kim7Jeong-Sun Yang8Kyung-Chang Kim9Joo-Yeon Lee10Geum-Sook Hwang11Geum-Sook Hwang12Integrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Republic of KoreaIntegrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaCollege of Health Sciences, Wonkwang University, Iksan, Republic of KoreaIntegrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Republic of KoreaBioinformatics Department, Theragen Bio, Seongnam, Republic of KoreaNational Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of KoreaNational Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of KoreaNational Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of KoreaNational Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of KoreaIntegrated Metabolomics Research Group, Metropolitan Seoul Center, Korea Basic Science Institute, Seoul, Republic of KoreaCollege of Pharmacy, Chung-Ang University, Seoul, Republic of KoreaIntroductionThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune responses and metabolism induced by these variants. MethodsHere, metabolomics combined with transcriptomics was performed to elucidate the immunometabolic changes in the lung of hamsters infected with delta and omicron variants.ResultsBoth variants caused acute inflammation and lung pathology in intranasally infected hamsters. Principal component analysis uncovered the delta variant significantly altered lung metabolite levels between the pre- and post-infection states. Additionally, metabolic pathways determined by assessment of metabolites and genes in lung revealed significant alterations in arginine biosynthesis, glutathione metabolism, and tryptophan metabolism upon infection with both variants and closely linked to inflammatory cytokines, indicating immune activation and oxidative stress in response to both variants. These metabolic changes were also evident in the serum, validating the presence of systemic alterations corresponding to those identified in lung. Notably, the delta variant induced a more robust metabolic regulation than the omicron variant. DiscussionThe study suggests that multi-omics is a valuable approach for understanding immunometabolic responses to infectious diseases, and providing insights for effective treatment strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473895/fullSARS-CoV-2metabolomicstranscriptomicsmetabolic pathwayimmune response |
| spellingShingle | Sunho Lee Sunho Lee Jueun Lee Kwang-Soo Lyoo Yourim Shin Yourim Shin Dong-Min Shin Jun-Won Kim Jeong-Sun Yang Kyung-Chang Kim Joo-Yeon Lee Geum-Sook Hwang Geum-Sook Hwang Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis Frontiers in Immunology SARS-CoV-2 metabolomics transcriptomics metabolic pathway immune response |
| title | Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis |
| title_full | Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis |
| title_fullStr | Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis |
| title_full_unstemmed | Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis |
| title_short | Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis |
| title_sort | unraveling metabolic signatures in sars cov 2 variant infections using multiomics analysis |
| topic | SARS-CoV-2 metabolomics transcriptomics metabolic pathway immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473895/full |
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