Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome
Chronic viral inflammation is associated with oxidative stress and changes in gut microbiota. The Mediterranean diet (MD), with recognized anti-inflammatory and antioxidant properties, modulates gut microorganisms, specifically on the interaction between extra virgin olive oil, a key component of th...
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MDPI AG
2024-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/11/1358 |
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| author | Amanda Cuevas-Sierra Victor de la O Andrea Higuera-Gómez Lourdes Chero-Sandoval Begoña de Cuevillas María Martínez-Urbistondo Victor Moreno-Torres Ilduara Pintos-Pascual Raquel Castejón J. Alfredo Martínez |
| author_facet | Amanda Cuevas-Sierra Victor de la O Andrea Higuera-Gómez Lourdes Chero-Sandoval Begoña de Cuevillas María Martínez-Urbistondo Victor Moreno-Torres Ilduara Pintos-Pascual Raquel Castejón J. Alfredo Martínez |
| author_sort | Amanda Cuevas-Sierra |
| collection | DOAJ |
| description | Chronic viral inflammation is associated with oxidative stress and changes in gut microbiota. The Mediterranean diet (MD), with recognized anti-inflammatory and antioxidant properties, modulates gut microorganisms, specifically on the interaction between extra virgin olive oil, a key component of the MD with well-documented antioxidant effects. This study investigated the influence of adherence to MD and antioxidant-rich foods (extra virgin olive oil) on biochemical, inflammatory, and microbiota profiles in patients with chronic inflammation defined as a prolonged inflammatory response due to immune dysregulation following the acute phase of the viral infection. Participants were classified into low (n = 54) and high (n = 134) MD adherence groups (cut-off of 7 points based on previous studies utilizing the same threshold in the assessment of MD adherence). Gut microbiota was sequenced using the 16S technique, and the adherence to MD was assessed using a validated questionnaire for a Spanish population. High adherence to the MD was linked to significant improvements in inflammatory and oxidative stress markers, including reductions in LDL-cholesterol, glucose, and lactate dehydrogenase (LDH) levels, an indicative of redox balance, as well as a significant higher consumption of antioxidant foods. Moreover, gut microbiota analysis revealed distinct compositional shifts and a lower abundance of the <i>Oscillibacter</i> genus in the high adherence group. Notably, a significant interaction was observed between MD adherence and extra virgin olive oil consumption, with <i>Oscillibacter</i> abundance influencing LDH levels, suggesting that the MD antioxidant properties may modulate inflammation through gut microbiota-mediated mechanisms. These findings provide new evidence that adherence to the Mediterranean diet can reduce inflammatory markers in patients with long-COVID-19, a population that has not been extensively studied, while also highlighting the potential role of the bacterial genus <i>Oscillibacter</i> in modulating this effect. |
| format | Article |
| id | doaj-art-1d2c19fdd6b346f89ad6bdfada09153d |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-1d2c19fdd6b346f89ad6bdfada09153d2024-11-26T17:47:07ZengMDPI AGAntioxidants2076-39212024-11-011311135810.3390/antiox13111358Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 SyndromeAmanda Cuevas-Sierra0Victor de la O1Andrea Higuera-Gómez2Lourdes Chero-Sandoval3Begoña de Cuevillas4María Martínez-Urbistondo5Victor Moreno-Torres6Ilduara Pintos-Pascual7Raquel Castejón8J. Alfredo Martínez9Precision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, 28222 Madrid, SpainFaculty of Health Sciences, International University of La Rioja (UNIR), 26006 Logroño, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, 28222 Madrid, SpainInternal Medicine Service, Puerta de Hierro Majadahonda University Hospital, 28222 Madrid, SpainPrecision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, 28049 Madrid, SpainChronic viral inflammation is associated with oxidative stress and changes in gut microbiota. The Mediterranean diet (MD), with recognized anti-inflammatory and antioxidant properties, modulates gut microorganisms, specifically on the interaction between extra virgin olive oil, a key component of the MD with well-documented antioxidant effects. This study investigated the influence of adherence to MD and antioxidant-rich foods (extra virgin olive oil) on biochemical, inflammatory, and microbiota profiles in patients with chronic inflammation defined as a prolonged inflammatory response due to immune dysregulation following the acute phase of the viral infection. Participants were classified into low (n = 54) and high (n = 134) MD adherence groups (cut-off of 7 points based on previous studies utilizing the same threshold in the assessment of MD adherence). Gut microbiota was sequenced using the 16S technique, and the adherence to MD was assessed using a validated questionnaire for a Spanish population. High adherence to the MD was linked to significant improvements in inflammatory and oxidative stress markers, including reductions in LDL-cholesterol, glucose, and lactate dehydrogenase (LDH) levels, an indicative of redox balance, as well as a significant higher consumption of antioxidant foods. Moreover, gut microbiota analysis revealed distinct compositional shifts and a lower abundance of the <i>Oscillibacter</i> genus in the high adherence group. Notably, a significant interaction was observed between MD adherence and extra virgin olive oil consumption, with <i>Oscillibacter</i> abundance influencing LDH levels, suggesting that the MD antioxidant properties may modulate inflammation through gut microbiota-mediated mechanisms. These findings provide new evidence that adherence to the Mediterranean diet can reduce inflammatory markers in patients with long-COVID-19, a population that has not been extensively studied, while also highlighting the potential role of the bacterial genus <i>Oscillibacter</i> in modulating this effect.https://www.mdpi.com/2076-3921/13/11/1358Mediterranean dietextra virgin olive oil<i>Oscillibacter</i>lactate dehydrogenasehealth benefitsantioxidant |
| spellingShingle | Amanda Cuevas-Sierra Victor de la O Andrea Higuera-Gómez Lourdes Chero-Sandoval Begoña de Cuevillas María Martínez-Urbistondo Victor Moreno-Torres Ilduara Pintos-Pascual Raquel Castejón J. Alfredo Martínez Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome Antioxidants Mediterranean diet extra virgin olive oil <i>Oscillibacter</i> lactate dehydrogenase health benefits antioxidant |
| title | Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome |
| title_full | Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome |
| title_fullStr | Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome |
| title_full_unstemmed | Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome |
| title_short | Mediterranean Diet and Olive Oil Redox Interactions on Lactate Dehydrogenase Mediated by Gut <i>Oscillibacter</i> in Patients with Long-COVID-19 Syndrome |
| title_sort | mediterranean diet and olive oil redox interactions on lactate dehydrogenase mediated by gut i oscillibacter i in patients with long covid 19 syndrome |
| topic | Mediterranean diet extra virgin olive oil <i>Oscillibacter</i> lactate dehydrogenase health benefits antioxidant |
| url | https://www.mdpi.com/2076-3921/13/11/1358 |
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