Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus
Background/Aim. Vitamin D insufficiency/deficiency is often present in patients with type-2 diabetes mellitus (DM) and could present a risk factor for rapid progression of diabetic nephropathy and for higher incidence of cardiovascular events. The aim of this study was to examine the influence of vi...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2020-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800113P.pdf |
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| author | Petrović Marijana Dragović Tamara Petrović Stanko Obrenčević Katarina Rančić Nemanja Đurašinović Tatjana Petrović Dejan Ignjatović Ljiljana Rabrenović Violeta Nenezić Nemanja Marinković Dejan Maksić Đoko |
| author_facet | Petrović Marijana Dragović Tamara Petrović Stanko Obrenčević Katarina Rančić Nemanja Đurašinović Tatjana Petrović Dejan Ignjatović Ljiljana Rabrenović Violeta Nenezić Nemanja Marinković Dejan Maksić Đoko |
| author_sort | Petrović Marijana |
| collection | DOAJ |
| description | Background/Aim. Vitamin D insufficiency/deficiency is often present in patients with type-2 diabetes mellitus (DM) and could present a risk factor for rapid progression of diabetic nephropathy and for higher incidence of cardiovascular events. The aim of this study was to examine the influence of vitamin D supplementation on proteinuria, cholesterol, triglycerides, C-reactive protein (CRP) and hemoglobin A1c in patients with type-2 DM and vitamin D insufficiency/ deficiency. Methods. This prospective, cohort study included 90 patients with type-2 DM and vitamin D insufficiency/ deficiency divided into 3 equal groups: with normal proteinura, with microproteinuria and with macroproteinuria. Therapy included six months of supplementation with cholecalciferol drops: first two months with 20,000 IU twice weekly, than if level of vitamin D was below normal the same dose was given next four months. If the level of vitamin D was normal 5,000 IU was given twice weekly. At the begining and at the end of the study the levels of urea, creatinine, fasting blood glucose, calcium, phosphorus, cholesterol, triglycerides, CRP, hemoglobin A1c, intact parathyroid hormone, 24-hour urine protein and creatinine clearance were determined. Levels of calcium, phosphorus and vitamin D were also checked 2 months after beginning of therapy due to possible correction of cholecalciferol dose. Results. The lowest level of vitamin D before therapy was found in patients with macroproteinuria, while at the end of the study the significantly higher level of vitamin D was found in all three groups. After 6 months of therapy a significant decrease of 24-hour urine protein, cholesterol, triglycerides, hemoglobin A1c in all three groups, and CRP in patients with normal proteinuria and microproteinuria were found. Significantly negative correlation between vitamin D and 24-hour urine protein, cholesterol and CRP was found in patients with macroproteinuria. Also, significantly negative correlation was found between vitamin D and hemoglobin A1c, in patients with normal proteinuria, vitamin D and CRP in patients with microproteinuria. Conclusion. A preventive use of high-dose cholecalciferol supplementation in patients with type-2 DM (with or without proteinuria) decreases cholesterol, triglycerides, proteinuria, CRP and hemoglobin A1c. |
| format | Article |
| id | doaj-art-1d2b320162ff4a31bc0e7701ae80dc44 |
| institution | DOAJ |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-1d2b320162ff4a31bc0e7701ae80dc442025-08-20T03:17:39ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202020-01-0177658258910.2298/VSP180525113P0042-84501800113PEffect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitusPetrović Marijana0Dragović Tamara1Petrović Stanko2Obrenčević Katarina3Rančić Nemanja4Đurašinović Tatjana5Petrović Dejan6Ignjatović Ljiljana7Rabrenović Violeta8Nenezić Nemanja9Marinković Dejan10Maksić Đoko11Military Medical Academy, Clinic for Nephrology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia + Military Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Nephrology, Belgrade, Serbia + Military Medical Academy, Clinic for Gastroenterology and Hepatology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Nephrology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, Serbia + Military Medical Academy, Center for Clinical Pharmacology, Belgrade, SerbiaMilitary Medical Academy, Institute of Medical Biochemistry, Belgrade, SerbiaClinical Center Kragujevac, Department of Internal Medicine, Kragujevac, Serbia + University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia Military Medical Academy, Clinic for Nephrology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, Clinic for Nephrology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Nephrology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaBackground/Aim. Vitamin D insufficiency/deficiency is often present in patients with type-2 diabetes mellitus (DM) and could present a risk factor for rapid progression of diabetic nephropathy and for higher incidence of cardiovascular events. The aim of this study was to examine the influence of vitamin D supplementation on proteinuria, cholesterol, triglycerides, C-reactive protein (CRP) and hemoglobin A1c in patients with type-2 DM and vitamin D insufficiency/ deficiency. Methods. This prospective, cohort study included 90 patients with type-2 DM and vitamin D insufficiency/ deficiency divided into 3 equal groups: with normal proteinura, with microproteinuria and with macroproteinuria. Therapy included six months of supplementation with cholecalciferol drops: first two months with 20,000 IU twice weekly, than if level of vitamin D was below normal the same dose was given next four months. If the level of vitamin D was normal 5,000 IU was given twice weekly. At the begining and at the end of the study the levels of urea, creatinine, fasting blood glucose, calcium, phosphorus, cholesterol, triglycerides, CRP, hemoglobin A1c, intact parathyroid hormone, 24-hour urine protein and creatinine clearance were determined. Levels of calcium, phosphorus and vitamin D were also checked 2 months after beginning of therapy due to possible correction of cholecalciferol dose. Results. The lowest level of vitamin D before therapy was found in patients with macroproteinuria, while at the end of the study the significantly higher level of vitamin D was found in all three groups. After 6 months of therapy a significant decrease of 24-hour urine protein, cholesterol, triglycerides, hemoglobin A1c in all three groups, and CRP in patients with normal proteinuria and microproteinuria were found. Significantly negative correlation between vitamin D and 24-hour urine protein, cholesterol and CRP was found in patients with macroproteinuria. Also, significantly negative correlation was found between vitamin D and hemoglobin A1c, in patients with normal proteinuria, vitamin D and CRP in patients with microproteinuria. Conclusion. A preventive use of high-dose cholecalciferol supplementation in patients with type-2 DM (with or without proteinuria) decreases cholesterol, triglycerides, proteinuria, CRP and hemoglobin A1c.http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800113P.pdfc-reactive proteincholesteroldiabetes mellitus, type 2diabetic nephropathiesglycated hemoglobin avitamin dtreatment outcomeproteinuriatriglycerides |
| spellingShingle | Petrović Marijana Dragović Tamara Petrović Stanko Obrenčević Katarina Rančić Nemanja Đurašinović Tatjana Petrović Dejan Ignjatović Ljiljana Rabrenović Violeta Nenezić Nemanja Marinković Dejan Maksić Đoko Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus Vojnosanitetski Pregled c-reactive protein cholesterol diabetes mellitus, type 2 diabetic nephropathies glycated hemoglobin a vitamin d treatment outcome proteinuria triglycerides |
| title | Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus |
| title_full | Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus |
| title_fullStr | Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus |
| title_full_unstemmed | Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus |
| title_short | Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus |
| title_sort | effect of vitamin d on proteinuria lipid status glicoregulation and c reactive protein in patients with type 2 diabetes mellitus |
| topic | c-reactive protein cholesterol diabetes mellitus, type 2 diabetic nephropathies glycated hemoglobin a vitamin d treatment outcome proteinuria triglycerides |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800113P.pdf |
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