Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication
A hallmark feature of cancer is its capacity to induce the development of new blood vessels. Anti-angiogenic therapies are commonly employed to combat various types of cancer. Despite notable advancements in this field, limited efficacy and resistance remain critical challenges. While anti-angiogeni...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235230422500100X |
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| author | Yulong Han Binqiang Zhu Shu Meng |
| author_facet | Yulong Han Binqiang Zhu Shu Meng |
| author_sort | Yulong Han |
| collection | DOAJ |
| description | A hallmark feature of cancer is its capacity to induce the development of new blood vessels. Anti-angiogenic therapies are commonly employed to combat various types of cancer. Despite notable advancements in this field, limited efficacy and resistance remain critical challenges. While anti-angiogenic therapy primarily targets endothelial cells within the abnormal vasculature, the origins of tumor vascular endothelial cells in solid tumors remain a subject of ongoing debate. Unraveling the origins of these endothelial cells is crucial for developing more effective strategies to combat tumor angiogenesis. This review summarizes the latest findings on the origins of endothelial cells in tumor angiogenesis and explores the progress, limitations, and future directions of anti-angiogenic therapy. |
| format | Article |
| id | doaj-art-1d24f5f25b754f52b647b45e7c6a7b4e |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-1d24f5f25b754f52b647b45e7c6a7b4e2025-08-24T05:13:05ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-11-0112610161110.1016/j.gendis.2025.101611Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implicationYulong Han0Binqiang Zhu1Shu Meng2State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510120, China; Department of Basic Science Research, Guangzhou National Laboratory, Guangzhou, Guangdong 510005, ChinaDepartment of Basic Science Research, Guangzhou National Laboratory, Guangzhou, Guangdong 510005, ChinaState Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510120, China; Department of Basic Science Research, Guangzhou National Laboratory, Guangzhou, Guangdong 510005, China; Corresponding author. Department of Basic Science Research, Guangzhou National Laboratory, Guangzhou, Guangdong 510005, China.A hallmark feature of cancer is its capacity to induce the development of new blood vessels. Anti-angiogenic therapies are commonly employed to combat various types of cancer. Despite notable advancements in this field, limited efficacy and resistance remain critical challenges. While anti-angiogenic therapy primarily targets endothelial cells within the abnormal vasculature, the origins of tumor vascular endothelial cells in solid tumors remain a subject of ongoing debate. Unraveling the origins of these endothelial cells is crucial for developing more effective strategies to combat tumor angiogenesis. This review summarizes the latest findings on the origins of endothelial cells in tumor angiogenesis and explores the progress, limitations, and future directions of anti-angiogenic therapy.http://www.sciencedirect.com/science/article/pii/S235230422500100XAngiogenesisAnti-angiogenic therapyOrigins of endothelial cellsTumor angiogenesisTumor endothelial cells |
| spellingShingle | Yulong Han Binqiang Zhu Shu Meng Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication Genes and Diseases Angiogenesis Anti-angiogenic therapy Origins of endothelial cells Tumor angiogenesis Tumor endothelial cells |
| title | Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication |
| title_full | Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication |
| title_fullStr | Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication |
| title_full_unstemmed | Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication |
| title_short | Endothelial cell in tumor angiogenesis: Origins, mechanisms, and therapeutic implication |
| title_sort | endothelial cell in tumor angiogenesis origins mechanisms and therapeutic implication |
| topic | Angiogenesis Anti-angiogenic therapy Origins of endothelial cells Tumor angiogenesis Tumor endothelial cells |
| url | http://www.sciencedirect.com/science/article/pii/S235230422500100X |
| work_keys_str_mv | AT yulonghan endothelialcellintumorangiogenesisoriginsmechanismsandtherapeuticimplication AT binqiangzhu endothelialcellintumorangiogenesisoriginsmechanismsandtherapeuticimplication AT shumeng endothelialcellintumorangiogenesisoriginsmechanismsandtherapeuticimplication |