Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy
Thrombosis and infection are pivotal clinical complications associated with interventional blood-contacting devices, leading to significant morbidity and mortality. To address these issues, we present a stepwise metal-catechol-(amine) (MCA) surface engineering strategy that efficiently integrates th...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24003967 |
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| author | Siyuan Yue Wentai Zhang Qing Ma Zhen Zhang Jing Lu Zhilu Yang |
| author_facet | Siyuan Yue Wentai Zhang Qing Ma Zhen Zhang Jing Lu Zhilu Yang |
| author_sort | Siyuan Yue |
| collection | DOAJ |
| description | Thrombosis and infection are pivotal clinical complications associated with interventional blood-contacting devices, leading to significant morbidity and mortality. To address these issues, we present a stepwise metal-catechol-(amine) (MCA) surface engineering strategy that efficiently integrates therapeutic nitric oxide (NO) gas and antibacterial peptide (ABP) onto catheters, ensuring balanced anti-thrombotic and anti-infective properties. First, copper ions were controllably incorporated with norepinephrine and hexanediamine through a one-step molecular/ion co-assembly process, creating a NO-generating and amine-rich MCA surface coating. Subsequently, azide-polyethylene glycol 4-N-hydroxysuccinimidyl and dibenzylcyclooctyne modified ABP were sequentially immobilized on the surface via amide coupling and bioorthogonal click chemistry, ensuring the dense grafting of ABP while maintaining the catalytic efficacy for NO. This efficient integration of ABP and NO-generating ability on the catheter surface provides potent antibacterial properties and ability to resist adhesion and activation of platelets, thus synergistically preventing infection and thrombosis. We anticipate that this synergistic modification strategy will offer an effective solution for advancing surface engineering and enhancing the clinical performance of biomedical devices. |
| format | Article |
| id | doaj-art-1d2117ee8c9041aaa6db66835d89c855 |
| institution | OA Journals |
| issn | 2452-199X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-1d2117ee8c9041aaa6db66835d89c8552025-08-20T02:18:46ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-12-014236637810.1016/j.bioactmat.2024.09.009Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategySiyuan Yue0Wentai Zhang1Qing Ma2Zhen Zhang3Jing Lu4Zhilu Yang5School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, ChinaDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, ChinaDongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, 610031, China; Corresponding author.Department of Anesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; Corresponding author.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, China; Corresponding author. School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Thrombosis and infection are pivotal clinical complications associated with interventional blood-contacting devices, leading to significant morbidity and mortality. To address these issues, we present a stepwise metal-catechol-(amine) (MCA) surface engineering strategy that efficiently integrates therapeutic nitric oxide (NO) gas and antibacterial peptide (ABP) onto catheters, ensuring balanced anti-thrombotic and anti-infective properties. First, copper ions were controllably incorporated with norepinephrine and hexanediamine through a one-step molecular/ion co-assembly process, creating a NO-generating and amine-rich MCA surface coating. Subsequently, azide-polyethylene glycol 4-N-hydroxysuccinimidyl and dibenzylcyclooctyne modified ABP were sequentially immobilized on the surface via amide coupling and bioorthogonal click chemistry, ensuring the dense grafting of ABP while maintaining the catalytic efficacy for NO. This efficient integration of ABP and NO-generating ability on the catheter surface provides potent antibacterial properties and ability to resist adhesion and activation of platelets, thus synergistically preventing infection and thrombosis. We anticipate that this synergistic modification strategy will offer an effective solution for advancing surface engineering and enhancing the clinical performance of biomedical devices.http://www.sciencedirect.com/science/article/pii/S2452199X24003967Nitric oxideAntibacterial peptideEfficient integrationAnticoagulantAnti-inflection |
| spellingShingle | Siyuan Yue Wentai Zhang Qing Ma Zhen Zhang Jing Lu Zhilu Yang Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy Bioactive Materials Nitric oxide Antibacterial peptide Efficient integration Anticoagulant Anti-inflection |
| title | Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy |
| title_full | Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy |
| title_fullStr | Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy |
| title_full_unstemmed | Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy |
| title_short | Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy |
| title_sort | engineering anti thrombogenic and anti infective catheters through a stepwise metal catechol amine surface engineering strategy |
| topic | Nitric oxide Antibacterial peptide Efficient integration Anticoagulant Anti-inflection |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24003967 |
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