<i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens
The spread of multidrug-resistant microbes has made it necessary and urgent to develop new strategies to deal with the infections they cause. Some of these are based on nanotechnology, which has revolutionized many fields in medicine. Evaluating the safety and efficacy of these new antimicrobial str...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/15/1/67 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841549047758848000 |
|---|---|
| author | Stefania Villani Matteo Calcagnile Christian Demitri Pietro Alifano |
| author_facet | Stefania Villani Matteo Calcagnile Christian Demitri Pietro Alifano |
| author_sort | Stefania Villani |
| collection | DOAJ |
| description | The spread of multidrug-resistant microbes has made it necessary and urgent to develop new strategies to deal with the infections they cause. Some of these are based on nanotechnology, which has revolutionized many fields in medicine. Evaluating the safety and efficacy of these new antimicrobial strategies requires testing in animal models before being tested in clinical trials. In this context, <i>Galleria mellonella</i> could represent a valid alternative to traditional mammalian and non-mammalian animal models, due to its low cost, ease of handling, and valuable biological properties to investigate host–pathogen interactions. The purpose of this review is to provide an updated overview of the literature concerning the use of <i>G. mellonella</i> larvae as an animal model to evaluate safety and efficacy of nanoparticles and nanomaterials, particularly, of those that are used or are under investigation to combat microbial pathogens. |
| format | Article |
| id | doaj-art-1d1ea3a55f2f48fea308f41485922494 |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-1d1ea3a55f2f48fea308f414859224942025-01-10T13:19:24ZengMDPI AGNanomaterials2079-49912025-01-011516710.3390/nano15010067<i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting PathogensStefania Villani0Matteo Calcagnile1Christian Demitri2Pietro Alifano3Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, ItalyDepartment of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, ItalyDepartment of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, ItalyDepartment of Experimental Medicine, University of Salento, Via Monteroni, 73100 Lecce, ItalyThe spread of multidrug-resistant microbes has made it necessary and urgent to develop new strategies to deal with the infections they cause. Some of these are based on nanotechnology, which has revolutionized many fields in medicine. Evaluating the safety and efficacy of these new antimicrobial strategies requires testing in animal models before being tested in clinical trials. In this context, <i>Galleria mellonella</i> could represent a valid alternative to traditional mammalian and non-mammalian animal models, due to its low cost, ease of handling, and valuable biological properties to investigate host–pathogen interactions. The purpose of this review is to provide an updated overview of the literature concerning the use of <i>G. mellonella</i> larvae as an animal model to evaluate safety and efficacy of nanoparticles and nanomaterials, particularly, of those that are used or are under investigation to combat microbial pathogens.https://www.mdpi.com/2079-4991/15/1/67<i>Galleria mellonella</i>nanoparticlesnanocompositesmultidrug-resistant microbestoxicityin vivo model |
| spellingShingle | Stefania Villani Matteo Calcagnile Christian Demitri Pietro Alifano <i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens Nanomaterials <i>Galleria mellonella</i> nanoparticles nanocomposites multidrug-resistant microbes toxicity in vivo model |
| title | <i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens |
| title_full | <i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens |
| title_fullStr | <i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens |
| title_full_unstemmed | <i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens |
| title_short | <i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens |
| title_sort | i galleria mellonella i greater wax moth as a reliable animal model to study the efficacy of nanomaterials in fighting pathogens |
| topic | <i>Galleria mellonella</i> nanoparticles nanocomposites multidrug-resistant microbes toxicity in vivo model |
| url | https://www.mdpi.com/2079-4991/15/1/67 |
| work_keys_str_mv | AT stefaniavillani igalleriamellonellaigreaterwaxmothasareliableanimalmodeltostudytheefficacyofnanomaterialsinfightingpathogens AT matteocalcagnile igalleriamellonellaigreaterwaxmothasareliableanimalmodeltostudytheefficacyofnanomaterialsinfightingpathogens AT christiandemitri igalleriamellonellaigreaterwaxmothasareliableanimalmodeltostudytheefficacyofnanomaterialsinfightingpathogens AT pietroalifano igalleriamellonellaigreaterwaxmothasareliableanimalmodeltostudytheefficacyofnanomaterialsinfightingpathogens |