Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review
Introduction: Enterocytozoon bieneusi (E.b) can cause opportunistic infections in immunocompromised patients, especially HIV/AIDS recipients, but currently, there are still few case reports of E.b infections in solid organ transplant recipients. As E.b cannot be diagnosed by routine exami...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-08-01
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| Series: | Case Reports in Gastroenterology |
| Online Access: | https://karger.com/article/doi/10.1159/000546660 |
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| author | Xiaohua Hong Lei Zeng Qiong Li Tiankai Yang Jing Zhou Huayou Li Yunchao Mo Shaoyi Zhuo Jiudong Ma Jingyue Cai Caipeng Xie |
| author_facet | Xiaohua Hong Lei Zeng Qiong Li Tiankai Yang Jing Zhou Huayou Li Yunchao Mo Shaoyi Zhuo Jiudong Ma Jingyue Cai Caipeng Xie |
| author_sort | Xiaohua Hong |
| collection | DOAJ |
| description |
Introduction: Enterocytozoon bieneusi (E.b) can cause opportunistic infections in immunocompromised patients, especially HIV/AIDS recipients, but currently, there are still few case reports of E.b infections in solid organ transplant recipients. As E.b cannot be diagnosed by routine examination and culture, it is often overlooked as a possible cause of chronic diarrhea in transplant recipients. With no known established guidelines for E.b, the effective and available treatment options are limited. Case Presentation: In this article, we reported a case of persistent chronic diarrhea and renal failure due to E.b infection after liver transplantation, which was definitively diagnosed using metagenomic next-generation sequencing (mNGS). Short course of albendazole was applied to the patient, resulting in rapid resolution of clinical symptoms and recovery of renal function. Conclusion: The case demonstrates the advantages of mNGS for the diagnosis of rare pathogenic bacterial infections, and together with the previous case reports, further suggests albendazole may serve as an effective therapy for the treatment of E.b for some patient. This article reviews relevant literature and provides an updated and more comprehensive reference for the selection of E.b treatment drugs. To be note, the overview showed there may be individualized differences in the efficacy of albendazole, which needs more study. |
| format | Article |
| id | doaj-art-1d1db3e9a7b9415a8773c499ca2c8409 |
| institution | Kabale University |
| issn | 1662-0631 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj-art-1d1db3e9a7b9415a8773c499ca2c84092025-08-20T04:01:57ZengKarger PublishersCase Reports in Gastroenterology1662-06312025-08-0119155656710.1159/000546660Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature ReviewXiaohua HongLei ZengQiong LiTiankai YangJing ZhouHuayou LiYunchao MoShaoyi ZhuoJiudong MaJingyue CaiCaipeng Xie Introduction: Enterocytozoon bieneusi (E.b) can cause opportunistic infections in immunocompromised patients, especially HIV/AIDS recipients, but currently, there are still few case reports of E.b infections in solid organ transplant recipients. As E.b cannot be diagnosed by routine examination and culture, it is often overlooked as a possible cause of chronic diarrhea in transplant recipients. With no known established guidelines for E.b, the effective and available treatment options are limited. Case Presentation: In this article, we reported a case of persistent chronic diarrhea and renal failure due to E.b infection after liver transplantation, which was definitively diagnosed using metagenomic next-generation sequencing (mNGS). Short course of albendazole was applied to the patient, resulting in rapid resolution of clinical symptoms and recovery of renal function. Conclusion: The case demonstrates the advantages of mNGS for the diagnosis of rare pathogenic bacterial infections, and together with the previous case reports, further suggests albendazole may serve as an effective therapy for the treatment of E.b for some patient. This article reviews relevant literature and provides an updated and more comprehensive reference for the selection of E.b treatment drugs. To be note, the overview showed there may be individualized differences in the efficacy of albendazole, which needs more study. https://karger.com/article/doi/10.1159/000546660 |
| spellingShingle | Xiaohua Hong Lei Zeng Qiong Li Tiankai Yang Jing Zhou Huayou Li Yunchao Mo Shaoyi Zhuo Jiudong Ma Jingyue Cai Caipeng Xie Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review Case Reports in Gastroenterology |
| title | Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review |
| title_full | Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review |
| title_fullStr | Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review |
| title_full_unstemmed | Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review |
| title_short | Infection of Enterocytozoon bieneusi in a Patient with Long-Term Immunosuppression after Liver Transplantation: A Case Report and Literature Review |
| title_sort | infection of enterocytozoon bieneusi in a patient with long term immunosuppression after liver transplantation a case report and literature review |
| url | https://karger.com/article/doi/10.1159/000546660 |
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