Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells
Ejiao jelly’s main ingredients include donkey-hide gelatin, walnuts, and black sesame seeds, which are rich in active components and possess certain antioxidant properties. This study employed four different extraction methods to obtain active substances from commercial Ejiao jelly. Based on the ana...
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| Format: | Article |
| Language: | English |
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Academy of National Food and Strategic Reserves Administration
2025-07-01
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| Series: | Liang you shipin ke-ji |
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| Online Access: | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20250417 |
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| author | MENG Ling-feng LI Cong WEI Zi-cheng MA Xue-ying ZHANG Jian-ling YUAN Yu-jiao YU Qun FAN Liu-ping |
| author_facet | MENG Ling-feng LI Cong WEI Zi-cheng MA Xue-ying ZHANG Jian-ling YUAN Yu-jiao YU Qun FAN Liu-ping |
| author_sort | MENG Ling-feng |
| collection | DOAJ |
| description | Ejiao jelly’s main ingredients include donkey-hide gelatin, walnuts, and black sesame seeds, which are rich in active components and possess certain antioxidant properties. This study employed four different extraction methods to obtain active substances from commercial Ejiao jelly. Based on the analysis of active components, in vitro hyaluronic acid inhibition tests, and SZ95 cell experiments, we explored the skincare effects of Ejiao jelly. The results showed that Ejiao jelly could significantly inhibit hyaluronidase activity, with the alcoholic extract of Ejiao jelly demonstrating the best inhibitory effect, reaching an inhibition rate of 64.58%1.80%. The cytotoxicity of Ejiao jelly extracts on SZ95 cells was tested using the CCK-8 method, revealing no cytotoxicity within the concentration range of 25-400 g/mL. The inhibitory effect of Ejiao jelly extracts on lipid synthesis in SZ95 cells was concentration-dependent. The alcoholic extract of Ejiao jelly at 400 g/mL showed the strongest effect in reducing lipid content in SZ95 cells, with an inhibition rate of 47.90%4.88%. This research provides a theoretical basis for investigating the skincare benefits of Ejiao jelly and has practical application value. |
| format | Article |
| id | doaj-art-1d1db19f21b74cf9a940da516c0ffffc |
| institution | Kabale University |
| issn | 1007-7561 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Academy of National Food and Strategic Reserves Administration |
| record_format | Article |
| series | Liang you shipin ke-ji |
| spelling | doaj-art-1d1db19f21b74cf9a940da516c0ffffc2025-08-20T04:02:32ZengAcademy of National Food and Strategic Reserves AdministrationLiang you shipin ke-ji1007-75612025-07-0133411712410.16210/j.cnki.1007-7561.2025.04.016Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 CellsMENG Ling-feng0LI Cong1WEI Zi-cheng2MA Xue-ying3ZHANG Jian-ling4YUAN Yu-jiao5YU Qun6FAN Liu-ping7Shandong Key Laboratory of Gum Drug Research and Development, Donge Ejiao Co., LTD., Liaocheng, Shandong 252200, China; Liaocheng Key Laboratory of Functional food research and development, Donge Ejiao Health Products Co., LTD., Liaocheng, Shandong 252200, ChinaShandong Key Laboratory of Gum Drug Research and Development, Donge Ejiao Co., LTD., Liaocheng, Shandong 252200, China; Liaocheng Key Laboratory of Functional food research and development, Donge Ejiao Health Products Co., LTD., Liaocheng, Shandong 252200, ChinaShandong Key Laboratory of Gum Drug Research and Development, Donge Ejiao Co., LTD., Liaocheng, Shandong 252200, China; Liaocheng Key Laboratory of Functional food research and development, Donge Ejiao Health Products Co., LTD., Liaocheng, Shandong 252200, ChinaShandong Key Laboratory of Gum Drug Research and Development, Donge Ejiao Co., LTD., Liaocheng, Shandong 252200, China; Liaocheng Key Laboratory of Functional food research and development, Donge Ejiao Health Products Co., LTD., Liaocheng, Shandong 252200, ChinaShandong Key Laboratory of Gum Drug Research and Development, Donge Ejiao Co., LTD., Liaocheng, Shandong 252200, China; Liaocheng Key Laboratory of Functional food research and development, Donge Ejiao Health Products Co., LTD., Liaocheng, Shandong 252200, ChinaShandong Key Laboratory of Gum Drug Research and Development, Donge Ejiao Co., LTD., Liaocheng, Shandong 252200, China; Liaocheng Key Laboratory of Functional food research and development, Donge Ejiao Health Products Co., LTD., Liaocheng, Shandong 252200, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaEjiao jelly’s main ingredients include donkey-hide gelatin, walnuts, and black sesame seeds, which are rich in active components and possess certain antioxidant properties. This study employed four different extraction methods to obtain active substances from commercial Ejiao jelly. Based on the analysis of active components, in vitro hyaluronic acid inhibition tests, and SZ95 cell experiments, we explored the skincare effects of Ejiao jelly. The results showed that Ejiao jelly could significantly inhibit hyaluronidase activity, with the alcoholic extract of Ejiao jelly demonstrating the best inhibitory effect, reaching an inhibition rate of 64.58%1.80%. The cytotoxicity of Ejiao jelly extracts on SZ95 cells was tested using the CCK-8 method, revealing no cytotoxicity within the concentration range of 25-400 g/mL. The inhibitory effect of Ejiao jelly extracts on lipid synthesis in SZ95 cells was concentration-dependent. The alcoholic extract of Ejiao jelly at 400 g/mL showed the strongest effect in reducing lipid content in SZ95 cells, with an inhibition rate of 47.90%4.88%. This research provides a theoretical basis for investigating the skincare benefits of Ejiao jelly and has practical application value.http://lyspkj.ijournal.cn/lyspkj/article/abstract/20250417ejiao jellyhyaluronidasesz95oil-control effect |
| spellingShingle | MENG Ling-feng LI Cong WEI Zi-cheng MA Xue-ying ZHANG Jian-ling YUAN Yu-jiao YU Qun FAN Liu-ping Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells Liang you shipin ke-ji ejiao jelly hyaluronidase sz95 oil-control effect |
| title | Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells |
| title_full | Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells |
| title_fullStr | Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells |
| title_full_unstemmed | Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells |
| title_short | Inhibitory Effect of Ejiao Jelly Extract on Hyaluronidase Activity and Its Influence on Lipid Synthesis in SZ95 Cells |
| title_sort | inhibitory effect of ejiao jelly extract on hyaluronidase activity and its influence on lipid synthesis in sz95 cells |
| topic | ejiao jelly hyaluronidase sz95 oil-control effect |
| url | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20250417 |
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