Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT...
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| Main Authors: | David J. Blacker, David Prentice, Anthony Alvaro, Timothy R. Bates, Michael Bynevelt, Andrew Kelly, Lay Kun Kho, Edith Kohler, Graeme J. Hankey, Andrew Thompson, Taryn Major |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/362961 |
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