Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/362961 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307131412480000 |
|---|---|
| author | David J. Blacker David Prentice Anthony Alvaro Timothy R. Bates Michael Bynevelt Andrew Kelly Lay Kun Kho Edith Kohler Graeme J. Hankey Andrew Thompson Taryn Major |
| author_facet | David J. Blacker David Prentice Anthony Alvaro Timothy R. Bates Michael Bynevelt Andrew Kelly Lay Kun Kho Edith Kohler Graeme J. Hankey Andrew Thompson Taryn Major |
| author_sort | David J. Blacker |
| collection | DOAJ |
| description | Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed. |
| format | Article |
| id | doaj-art-1d0eb60e3c9f4d0295247bbca4fec341 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-1d0eb60e3c9f4d0295247bbca4fec3412025-08-20T03:54:51ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/362961362961Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising MinocyclineDavid J. Blacker0David Prentice1Anthony Alvaro2Timothy R. Bates3Michael Bynevelt4Andrew Kelly5Lay Kun Kho6Edith Kohler7Graeme J. Hankey8Andrew Thompson9Taryn Major10Department of Neurology and Clinical Neurophysiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia and School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, AustraliaDepartment of General Medicine, Royal Perth Hospital, Perth, WA 6000, AustraliaDepartment of Neurology, Fremantle Hospital, Fremantle, WA 6160, AustraliaStroke Unit, Swan District Hospital, Middle Swan WA 6056, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, AustraliaDepartment of Neurological Intervention and Imaging Service of Western Australia, Sir Charles Gairdner Hospital, Nedlands, WA 6009, AustraliaDepartment of Neurology, Fremantle Hospital, Fremantle, WA 6160, AustraliaStroke Unit, Swan District Hospital, Middle Swan, WA 6056, AustraliaDepartment of General Medicine, Royal Perth Hospital, Perth, WA 6000, AustraliaDepartment of Neurology, Royal Perth Hospital, Perth WA 6000, School of Medicine and Pharmacology, The University of Western Australia, Nedlands, WA 6009, AustraliaDepartment of Neurological Intervention and Imaging Service of Western Australia, Sir Charles Gairdner Hospital, Nedlands, WA 6009, AustraliaData Analysis Australia, Nedlands, WA 6009, AustraliaHaemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.http://dx.doi.org/10.1155/2013/362961 |
| spellingShingle | David J. Blacker David Prentice Anthony Alvaro Timothy R. Bates Michael Bynevelt Andrew Kelly Lay Kun Kho Edith Kohler Graeme J. Hankey Andrew Thompson Taryn Major Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline Stroke Research and Treatment |
| title | Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline |
| title_full | Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline |
| title_fullStr | Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline |
| title_full_unstemmed | Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline |
| title_short | Reducing Haemorrhagic Transformation after Thrombolysis for Stroke: A Strategy Utilising Minocycline |
| title_sort | reducing haemorrhagic transformation after thrombolysis for stroke a strategy utilising minocycline |
| url | http://dx.doi.org/10.1155/2013/362961 |
| work_keys_str_mv | AT davidjblacker reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT davidprentice reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT anthonyalvaro reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT timothyrbates reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT michaelbynevelt reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT andrewkelly reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT laykunkho reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT edithkohler reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT graemejhankey reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT andrewthompson reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline AT tarynmajor reducinghaemorrhagictransformationafterthrombolysisforstrokeastrategyutilisingminocycline |