Malignant transformation in oral epithelial dysplasticlesions: An observational study
Introduction: This research study is a comprehensive analysis of cases oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) over the past decade, with a particular focus on eliciting the frequency of malignant transformation (MT) of OED within this group of 328 patients in a terti...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Sarajevo
2025-04-01
|
| Series: | Journal of Health Sciences |
| Subjects: | |
| Online Access: | https://jhsci.ba/ojs/index.php/jhsci/article/view/2714 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849469676826918912 |
|---|---|
| author | Anuhya Jayanthi Sagar Krishna Sunitha Carnelio Vasudeva Guddattu Spoorti Kulkarni |
| author_facet | Anuhya Jayanthi Sagar Krishna Sunitha Carnelio Vasudeva Guddattu Spoorti Kulkarni |
| author_sort | Anuhya Jayanthi |
| collection | DOAJ |
| description |
Introduction: This research study is a comprehensive analysis of cases oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) over the past decade, with a particular focus on eliciting the frequency of malignant transformation (MT) of OED within this group of 328 patients in a tertiary center of Karnataka. Aim of this study is to investigate the likely correlation between OSCC and OED with demographic details, clinical parameters, and risk factors, highlighting the frequency of MT of OED to OSCC.
Methods: This study, retrospectively analyses 328 cases of OSCC (n = 236) and OED (92) using the medical records of the patients over 10 years, out of which 29 cases of OED had undergone MT. Statistical analysis was conducted using the Chi-square and Wilcoxon rank sum tests.
Results: The median IQR of MT (n = 29) was found to be 34 months (within a range from 27 to 38 months). 51.7% of dysplastic cases had transformed into well-differentiated squamous cell carcinoma and 48.3% of dysplastic cases had transformed into moderately differentiated squamous cell carcinoma the risk of cancer increased with severe dysplasia, the median age was found to be 54, which was prevalent in the buccal mucosa and male patients with a habit history.
Conclusion: Severe dysplasia could serve as a significant indicator for evaluating MT risk in patients with potentially malignant lesions; Moreover, our data indicated that patients with OED require long-term monitoring and clinical follow-up, thereby aiding in early intervention.
|
| format | Article |
| id | doaj-art-1d0a5c52b99e47bcb90a16c64ece217c |
| institution | Kabale University |
| issn | 2232-7576 1986-8049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | University of Sarajevo |
| record_format | Article |
| series | Journal of Health Sciences |
| spelling | doaj-art-1d0a5c52b99e47bcb90a16c64ece217c2025-08-20T03:25:23ZengUniversity of SarajevoJournal of Health Sciences2232-75761986-80492025-04-0115110.17532/jhsci.2025.2714Malignant transformation in oral epithelial dysplasticlesions: An observational studyAnuhya Jayanthi0https://orcid.org/0009-0008-0401-4326Sagar Krishna1https://orcid.org/0009-0003-8467-2313Sunitha Carnelio2Vasudeva Guddattu3Spoorti Kulkarni4https://orcid.org/0000-0003-3118-7595Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, IndiaDepartment of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, IndiaDepartment of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, IndiaDepartment of Data Science of the Prasanna School of Public Health at Manipal Academy of Higher Education, Manipal, Karnataka, IndiaDepartment of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India Introduction: This research study is a comprehensive analysis of cases oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) over the past decade, with a particular focus on eliciting the frequency of malignant transformation (MT) of OED within this group of 328 patients in a tertiary center of Karnataka. Aim of this study is to investigate the likely correlation between OSCC and OED with demographic details, clinical parameters, and risk factors, highlighting the frequency of MT of OED to OSCC. Methods: This study, retrospectively analyses 328 cases of OSCC (n = 236) and OED (92) using the medical records of the patients over 10 years, out of which 29 cases of OED had undergone MT. Statistical analysis was conducted using the Chi-square and Wilcoxon rank sum tests. Results: The median IQR of MT (n = 29) was found to be 34 months (within a range from 27 to 38 months). 51.7% of dysplastic cases had transformed into well-differentiated squamous cell carcinoma and 48.3% of dysplastic cases had transformed into moderately differentiated squamous cell carcinoma the risk of cancer increased with severe dysplasia, the median age was found to be 54, which was prevalent in the buccal mucosa and male patients with a habit history. Conclusion: Severe dysplasia could serve as a significant indicator for evaluating MT risk in patients with potentially malignant lesions; Moreover, our data indicated that patients with OED require long-term monitoring and clinical follow-up, thereby aiding in early intervention. https://jhsci.ba/ojs/index.php/jhsci/article/view/2714Carcinomasquamous cellmouth neoplasmshyperplasia |
| spellingShingle | Anuhya Jayanthi Sagar Krishna Sunitha Carnelio Vasudeva Guddattu Spoorti Kulkarni Malignant transformation in oral epithelial dysplasticlesions: An observational study Journal of Health Sciences Carcinoma squamous cell mouth neoplasms hyperplasia |
| title | Malignant transformation in oral epithelial dysplasticlesions: An observational study |
| title_full | Malignant transformation in oral epithelial dysplasticlesions: An observational study |
| title_fullStr | Malignant transformation in oral epithelial dysplasticlesions: An observational study |
| title_full_unstemmed | Malignant transformation in oral epithelial dysplasticlesions: An observational study |
| title_short | Malignant transformation in oral epithelial dysplasticlesions: An observational study |
| title_sort | malignant transformation in oral epithelial dysplasticlesions an observational study |
| topic | Carcinoma squamous cell mouth neoplasms hyperplasia |
| url | https://jhsci.ba/ojs/index.php/jhsci/article/view/2714 |
| work_keys_str_mv | AT anuhyajayanthi malignanttransformationinoralepithelialdysplasticlesionsanobservationalstudy AT sagarkrishna malignanttransformationinoralepithelialdysplasticlesionsanobservationalstudy AT sunithacarnelio malignanttransformationinoralepithelialdysplasticlesionsanobservationalstudy AT vasudevaguddattu malignanttransformationinoralepithelialdysplasticlesionsanobservationalstudy AT spoortikulkarni malignanttransformationinoralepithelialdysplasticlesionsanobservationalstudy |