Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis

Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis

Abstract Background Cutaneous melanoma (CM) is strongly associated with ultraviolet (UV) radiation, which contributes to the transformation of melanocytes into melanoma by inducing specific DNA damage. Here, we investigated the causal relationship between CM and genes related to sun-damaged skin, ex...

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Bibliographic Details
Main Authors: Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Cutaneous melanoma
CTSS
Mendelian randomization
Sensitivity analysis
Immunotherapy
Online Access:https://doi.org/10.1186/s12885-025-13481-w
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