Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis
Background/Aim. Unilateral optic neuritis (ON), and its pathological substrate, retrobulbar neuritis (RBN), is a common presentation of multiple sclerosis (MS). The aim of the study was to determine the diagnostic and prognostic value of structural and functional examination using novel ‘swept-sourc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2023-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200064K.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307128269897728 |
|---|---|
| author | Katanić-Pasovski Katarina Rančić Nemanja Pasovski Viktor Sajić Marija Resan Mirko Dinčić Evica |
| author_facet | Katanić-Pasovski Katarina Rančić Nemanja Pasovski Viktor Sajić Marija Resan Mirko Dinčić Evica |
| author_sort | Katanić-Pasovski Katarina |
| collection | DOAJ |
| description | Background/Aim. Unilateral optic neuritis (ON), and its pathological substrate, retrobulbar neuritis (RBN), is a common presentation of multiple sclerosis (MS). The aim of the study was to determine the diagnostic and prognostic value of structural and functional examination using novel ‘swept-source’ optical coherence tomography (SS-OCT) and OCT angiography (OCTA) techniques in patients with MS who experienced RBN. Methods. For examining retinal structural and functional changes in both the affected and nonaffected eye of patients with MS, novel techniques, OCT and O CTA, w ere u sed. The obtained results w ere compared with the results of the same examination on the left and right eye of the healthy controls. Results. Using OCT, significant differences in the structural integrity and thickness of retinal layers between the eye in which RBN had been detected and the contralateral, nonaffected eye were found (83.73 ± 18.36 vs. 98.67 ± 11.84; p = 0.013). On the other hand, the functional examination of the macular vascular plexus did not show significant differences between the affected and the nonaffected eye in these patients (41.86 ± 1.52 vs. 42.52 ± 1.40; p = 0.228). Interestingly, comparing the nonaffected eye of patients with RBN and healthy controls, a significant difference in the thickness of the retinal layers between the contralateral eye of the patient and both healthy eyes of healthy subjects was found. OCT examination showed particularly significant thinning of the macular ganglion cell-inner plexiform layer (mGCIPL) (61.07 ± 5.04 vs. 67.53 ± 4.57; p < 0.001). Conclusion. Overall, our research showed that OCT and OCTA offer an unprecedented opportunity for a safe, reliable, and repetitive assessment of structural and functional retinal changes as invaluable diagnostic and prognostic tools, paving the way for a better understanding of pathogenic mechanisms underlying inflammatory demyelinating and neurodegenerative diseases. In addition, mGCIPL may be a particularly sensitive and reliable biomarker of pathological changes in MS and perhaps in other neurodegenerative diseases. |
| format | Article |
| id | doaj-art-1d0463b9ee7240e9981bb79c3fd291ea |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-1d0463b9ee7240e9981bb79c3fd291ea2025-08-20T03:54:51ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202023-01-0180541242010.2298/VSP220525064K0042-84502200064KEvaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosisKatanić-Pasovski Katarina0Rančić Nemanja1https://orcid.org/0000-0002-5122-8094Pasovski Viktor2Sajić Marija3https://orcid.org/0000-0002-4050-7477Resan Mirko4Dinčić Evica5Military Medical Academy, Clinic for Ophthalmology, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia + Military Medical Academy, Center for Clinical Pharmacology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Neurology, Belgrade, SerbiaUCL Queen Square Institute of Neurology, Department of Neuroinflammation, London, United KingdomMilitary Medical Academy, Clinic for Ophthalmology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, Clinic for Neurology, Belgrade, SerbiaBackground/Aim. Unilateral optic neuritis (ON), and its pathological substrate, retrobulbar neuritis (RBN), is a common presentation of multiple sclerosis (MS). The aim of the study was to determine the diagnostic and prognostic value of structural and functional examination using novel ‘swept-source’ optical coherence tomography (SS-OCT) and OCT angiography (OCTA) techniques in patients with MS who experienced RBN. Methods. For examining retinal structural and functional changes in both the affected and nonaffected eye of patients with MS, novel techniques, OCT and O CTA, w ere u sed. The obtained results w ere compared with the results of the same examination on the left and right eye of the healthy controls. Results. Using OCT, significant differences in the structural integrity and thickness of retinal layers between the eye in which RBN had been detected and the contralateral, nonaffected eye were found (83.73 ± 18.36 vs. 98.67 ± 11.84; p = 0.013). On the other hand, the functional examination of the macular vascular plexus did not show significant differences between the affected and the nonaffected eye in these patients (41.86 ± 1.52 vs. 42.52 ± 1.40; p = 0.228). Interestingly, comparing the nonaffected eye of patients with RBN and healthy controls, a significant difference in the thickness of the retinal layers between the contralateral eye of the patient and both healthy eyes of healthy subjects was found. OCT examination showed particularly significant thinning of the macular ganglion cell-inner plexiform layer (mGCIPL) (61.07 ± 5.04 vs. 67.53 ± 4.57; p < 0.001). Conclusion. Overall, our research showed that OCT and OCTA offer an unprecedented opportunity for a safe, reliable, and repetitive assessment of structural and functional retinal changes as invaluable diagnostic and prognostic tools, paving the way for a better understanding of pathogenic mechanisms underlying inflammatory demyelinating and neurodegenerative diseases. In addition, mGCIPL may be a particularly sensitive and reliable biomarker of pathological changes in MS and perhaps in other neurodegenerative diseases.https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200064K.pdfangiographydiagnosismultiple sclerosisoptic neuritistomography, optical coherence |
| spellingShingle | Katanić-Pasovski Katarina Rančić Nemanja Pasovski Viktor Sajić Marija Resan Mirko Dinčić Evica Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis Vojnosanitetski Pregled angiography diagnosis multiple sclerosis optic neuritis tomography, optical coherence |
| title | Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis |
| title_full | Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis |
| title_fullStr | Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis |
| title_full_unstemmed | Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis |
| title_short | Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis |
| title_sort | evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis |
| topic | angiography diagnosis multiple sclerosis optic neuritis tomography, optical coherence |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502200064K.pdf |
| work_keys_str_mv | AT katanicpasovskikatarina evaluationoftheretinalmorphologicalandfunctionalfindingsinopticneuritisrelatedtomultiplesclerosis AT rancicnemanja evaluationoftheretinalmorphologicalandfunctionalfindingsinopticneuritisrelatedtomultiplesclerosis AT pasovskiviktor evaluationoftheretinalmorphologicalandfunctionalfindingsinopticneuritisrelatedtomultiplesclerosis AT sajicmarija evaluationoftheretinalmorphologicalandfunctionalfindingsinopticneuritisrelatedtomultiplesclerosis AT resanmirko evaluationoftheretinalmorphologicalandfunctionalfindingsinopticneuritisrelatedtomultiplesclerosis AT dincicevica evaluationoftheretinalmorphologicalandfunctionalfindingsinopticneuritisrelatedtomultiplesclerosis |