Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression

Early childhood autism, or autism spectrum disorders, is an extremely heterogeneous group of conditions that share similar symptoms of dysontogenesis. The most significant comorbidity in patients with autism is epilepsy, which is still associated with a variety of controversies. The present article...

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Main Authors: G. V. Kuzmich, A. N. Sinelnikova, K. Yu. Mukhin
Format: Article
Language:Russian
Published: ABV-press 2019-05-01
Series:Русский журнал детской неврологии
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Online Access:https://rjdn.abvpress.ru/jour/article/view/285
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author G. V. Kuzmich
A. N. Sinelnikova
K. Yu. Mukhin
author_facet G. V. Kuzmich
A. N. Sinelnikova
K. Yu. Mukhin
author_sort G. V. Kuzmich
collection DOAJ
description Early childhood autism, or autism spectrum disorders, is an extremely heterogeneous group of conditions that share similar symptoms of dysontogenesis. The most significant comorbidity in patients with autism is epilepsy, which is still associated with a variety of controversies. The present article covers the most controversial aspects of comorbidity between autism and epilepsy, including the impact of psychopharmacotherapy on the risk of epilepsy, clinical significance of epileptiform activity on the electroencephalogram in patients without epilepsy, and criteria for and prevalence of autistic epileptiform regression syndrome. We found that there is still a lack of reliable evidence for the majority of issues related to the combination of autism and epilepsy. We emphasize the need for further studies. We also provide a detailed description of the history, criteria, prevalence, and clinical examples of autistic epileptiform regression syndrome.
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series Русский журнал детской неврологии
spelling doaj-art-1d02e61fd3744fffa707c8b282630d1c2025-08-20T02:56:08ZrusABV-pressРусский журнал детской неврологии2073-88032412-91782019-05-01141404810.17650/2073-8803-2019-14-1-40-48197Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regressionG. V. Kuzmich0A. N. Sinelnikova1K. Yu. Mukhin2Svt. Luka’s Institute of Child Neurology and Epilepsy; Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva, Moscow City Department of HealthPeoples’ Friendship University of RussiaSvt. Luka’s Institute of Child Neurology and EpilepsyEarly childhood autism, or autism spectrum disorders, is an extremely heterogeneous group of conditions that share similar symptoms of dysontogenesis. The most significant comorbidity in patients with autism is epilepsy, which is still associated with a variety of controversies. The present article covers the most controversial aspects of comorbidity between autism and epilepsy, including the impact of psychopharmacotherapy on the risk of epilepsy, clinical significance of epileptiform activity on the electroencephalogram in patients without epilepsy, and criteria for and prevalence of autistic epileptiform regression syndrome. We found that there is still a lack of reliable evidence for the majority of issues related to the combination of autism and epilepsy. We emphasize the need for further studies. We also provide a detailed description of the history, criteria, prevalence, and clinical examples of autistic epileptiform regression syndrome.https://rjdn.abvpress.ru/jour/article/view/285autismautism spectrum disordersepilepsypsychopharmacotherapysubclinical epileptiform activityautistic epileptiform regression
spellingShingle G. V. Kuzmich
A. N. Sinelnikova
K. Yu. Mukhin
Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression
Русский журнал детской неврологии
autism
autism spectrum disorders
epilepsy
psychopharmacotherapy
subclinical epileptiform activity
autistic epileptiform regression
title Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression
title_full Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression
title_fullStr Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression
title_full_unstemmed Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression
title_short Controversial issues in comorbidity between epilepsy and autism: subclinical epileptiform activity and autistic epileptiform regression
title_sort controversial issues in comorbidity between epilepsy and autism subclinical epileptiform activity and autistic epileptiform regression
topic autism
autism spectrum disorders
epilepsy
psychopharmacotherapy
subclinical epileptiform activity
autistic epileptiform regression
url https://rjdn.abvpress.ru/jour/article/view/285
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AT ansinelnikova controversialissuesincomorbiditybetweenepilepsyandautismsubclinicalepileptiformactivityandautisticepileptiformregression
AT kyumukhin controversialissuesincomorbiditybetweenepilepsyandautismsubclinicalepileptiformactivityandautisticepileptiformregression