Photocatalytic therapy via photoinduced redox imbalance in biological system
Abstract Redox balance is essential for sustaining normal physiological metabolic activities of life. In this study, we present a photocatalytic system to perturb the balance of NADH/NAD+ in oxygen-free conditions, achieving photocatalytic therapy to cure anaerobic bacterial infected periodontitis....
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55060-w |
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| author | Kun Zhou Lili Du Rui Ding Letian Xu Shuai Shi Siyuan Wang Zaiyu Wang Guoqing Zhang Gang He Zheng Zhao Ben Zhong Tang |
| author_facet | Kun Zhou Lili Du Rui Ding Letian Xu Shuai Shi Siyuan Wang Zaiyu Wang Guoqing Zhang Gang He Zheng Zhao Ben Zhong Tang |
| author_sort | Kun Zhou |
| collection | DOAJ |
| description | Abstract Redox balance is essential for sustaining normal physiological metabolic activities of life. In this study, we present a photocatalytic system to perturb the balance of NADH/NAD+ in oxygen-free conditions, achieving photocatalytic therapy to cure anaerobic bacterial infected periodontitis. Under light irradiation, the catalyst TBSMSPy+ can bind bacterial DNA and initiate the generation of radical species through a multi-step electron transfer process. It catalyzes the conversion from NADH to NAD+ (the turnover frequency up to 60.7 min−1), inhibits ATP synthesis, disrupts the energy supply required for DNA replication, and successfully accomplishes photocatalytic sterilization in an oxygen-free environment. The catalyst participates in the redox reaction, interfering with the balance of NADH/NAD+ contents under irradiation, so we termed this action as photoinduced redox imbalance. Additionally, animal experiments in male rats also validate that the TBSMSPy+ could effectively catalyze the NADH oxidation, suppress metabolism and stimulate osteogenesis. Our research substantiates the concept of photoinduced redox imbalance and the application of photocatalytic therapy, further advocating the development of such catalyst based on photoinduced redox imbalance strategy for oxygen-free phototherapy. |
| format | Article |
| id | doaj-art-1d026bad7ff64ea0bfb146db0fb41952 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-1d026bad7ff64ea0bfb146db0fb419522025-08-20T02:20:45ZengNature PortfolioNature Communications2041-17232024-12-0115111310.1038/s41467-024-55060-wPhotocatalytic therapy via photoinduced redox imbalance in biological systemKun Zhou0Lili Du1Rui Ding2Letian Xu3Shuai Shi4Siyuan Wang5Zaiyu Wang6Guoqing Zhang7Gang He8Zheng Zhao9Ben Zhong Tang10Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)Department of Chemistry, The University of Hong KongFrontier Institute of Science and Technology, Xi’an Jiaotong UniversityGuangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of TechnologyFrontier Institute of Science and Technology, Xi’an Jiaotong UniversitySchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and TechnologyUniversity of Science and Technology of ChinaFrontier Institute of Science and Technology, Xi’an Jiaotong UniversityClinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)Abstract Redox balance is essential for sustaining normal physiological metabolic activities of life. In this study, we present a photocatalytic system to perturb the balance of NADH/NAD+ in oxygen-free conditions, achieving photocatalytic therapy to cure anaerobic bacterial infected periodontitis. Under light irradiation, the catalyst TBSMSPy+ can bind bacterial DNA and initiate the generation of radical species through a multi-step electron transfer process. It catalyzes the conversion from NADH to NAD+ (the turnover frequency up to 60.7 min−1), inhibits ATP synthesis, disrupts the energy supply required for DNA replication, and successfully accomplishes photocatalytic sterilization in an oxygen-free environment. The catalyst participates in the redox reaction, interfering with the balance of NADH/NAD+ contents under irradiation, so we termed this action as photoinduced redox imbalance. Additionally, animal experiments in male rats also validate that the TBSMSPy+ could effectively catalyze the NADH oxidation, suppress metabolism and stimulate osteogenesis. Our research substantiates the concept of photoinduced redox imbalance and the application of photocatalytic therapy, further advocating the development of such catalyst based on photoinduced redox imbalance strategy for oxygen-free phototherapy.https://doi.org/10.1038/s41467-024-55060-w |
| spellingShingle | Kun Zhou Lili Du Rui Ding Letian Xu Shuai Shi Siyuan Wang Zaiyu Wang Guoqing Zhang Gang He Zheng Zhao Ben Zhong Tang Photocatalytic therapy via photoinduced redox imbalance in biological system Nature Communications |
| title | Photocatalytic therapy via photoinduced redox imbalance in biological system |
| title_full | Photocatalytic therapy via photoinduced redox imbalance in biological system |
| title_fullStr | Photocatalytic therapy via photoinduced redox imbalance in biological system |
| title_full_unstemmed | Photocatalytic therapy via photoinduced redox imbalance in biological system |
| title_short | Photocatalytic therapy via photoinduced redox imbalance in biological system |
| title_sort | photocatalytic therapy via photoinduced redox imbalance in biological system |
| url | https://doi.org/10.1038/s41467-024-55060-w |
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