Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism

Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism

Abstract Background Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, while the mechanism by which extracellular vesicles (EVs) promote chondrocyte regeneration remains unclear. The study assessed the effect of hypoxic mesenchymal stem cells (MSCs)-derived EVs on cartilag...

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Bibliographic Details
Main Authors: Haifeng Zhang, Yanmeng Yang, Yingnan Wu, Vinitha Denslin, Yi Wei Justin Koh, Ling Liu, Wenhai Zhuo, Wing Moon Raymond Lam, Yinxian Yu, James Hoi Po Hui, Zheng Yang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Osteoarthritis
Chondrocyte
Extracellular vesicles
Autophagy
miR-122-5p
DUSP2
Online Access:https://doi.org/10.1186/s13287-025-04412-4
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