Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives
Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the worl...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6380463 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850237655049043968 |
|---|---|
| author | Elisa Guarino Chiara Delli Poggi Giuseppina Emanuela Grieco Valeria Cenci Elena Ceccarelli Isabella Crisci Guido Sebastiani Francesco Dotta |
| author_facet | Elisa Guarino Chiara Delli Poggi Giuseppina Emanuela Grieco Valeria Cenci Elena Ceccarelli Isabella Crisci Guido Sebastiani Francesco Dotta |
| author_sort | Elisa Guarino |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screening for abnormal glucose levels is generally recommended as a routine component of care for pregnant women. However, additional biomarkers are needed in order to predict the onset or accurately monitor the status of gestational diabetes. Recently, microRNAs, a class of small noncoding RNAs demonstrated to modulate gene expression, have been proven to be secreted by cells of origin and can be found in many biological fluids such as serum or plasma. Such feature renders microRNAs as optimal biomarkers and sensors of in situ tissue alterations. Furthermore, secretion of microRNAs via exosomes has been reported to contribute to tissue cross talk, thus potentially represents, if disrupted, a mechanistic cause of tissue/cell dysfunction in a specific disease. In this review, we summarized the recent findings on circulating microRNAs and gestational diabetes mellitus with particular focus on the potential use of microRNAs as putative biomarkers of disease as well as a potential cause of GDM complications and β cell dysfunction. |
| format | Article |
| id | doaj-art-1cf9f258d1e343e6ad1fd34e1ca4c87b |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1cf9f258d1e343e6ad1fd34e1ca4c87b2025-08-20T02:01:42ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/63804636380463Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and PerspectivesElisa Guarino0Chiara Delli Poggi1Giuseppina Emanuela Grieco2Valeria Cenci3Elena Ceccarelli4Isabella Crisci5Guido Sebastiani6Francesco Dotta7UO Diabetologia, Azienda Ospedaliera Universitaria Senese, Siena, ItalyDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, ItalyDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, ItalyUO Diabetologia, Azienda Ospedaliera Universitaria Senese, Siena, ItalyDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, ItalyDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, ItalyDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, ItalyUO Diabetologia, Azienda Ospedaliera Universitaria Senese, Siena, ItalyGestational diabetes mellitus (GDM) is defined as any degree of carbohydrate intolerance, with onset or first recognition during second or third trimester of gestation. It is estimated that approximately 7% of all pregnancies are complicated by GDM and that its prevalence is rising all over the world. Thus, the screening for abnormal glucose levels is generally recommended as a routine component of care for pregnant women. However, additional biomarkers are needed in order to predict the onset or accurately monitor the status of gestational diabetes. Recently, microRNAs, a class of small noncoding RNAs demonstrated to modulate gene expression, have been proven to be secreted by cells of origin and can be found in many biological fluids such as serum or plasma. Such feature renders microRNAs as optimal biomarkers and sensors of in situ tissue alterations. Furthermore, secretion of microRNAs via exosomes has been reported to contribute to tissue cross talk, thus potentially represents, if disrupted, a mechanistic cause of tissue/cell dysfunction in a specific disease. In this review, we summarized the recent findings on circulating microRNAs and gestational diabetes mellitus with particular focus on the potential use of microRNAs as putative biomarkers of disease as well as a potential cause of GDM complications and β cell dysfunction.http://dx.doi.org/10.1155/2018/6380463 |
| spellingShingle | Elisa Guarino Chiara Delli Poggi Giuseppina Emanuela Grieco Valeria Cenci Elena Ceccarelli Isabella Crisci Guido Sebastiani Francesco Dotta Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives International Journal of Endocrinology |
| title | Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives |
| title_full | Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives |
| title_fullStr | Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives |
| title_full_unstemmed | Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives |
| title_short | Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives |
| title_sort | circulating micrornas as biomarkers of gestational diabetes mellitus updates and perspectives |
| url | http://dx.doi.org/10.1155/2018/6380463 |
| work_keys_str_mv | AT elisaguarino circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT chiaradellipoggi circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT giuseppinaemanuelagrieco circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT valeriacenci circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT elenaceccarelli circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT isabellacrisci circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT guidosebastiani circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives AT francescodotta circulatingmicrornasasbiomarkersofgestationaldiabetesmellitusupdatesandperspectives |