The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma

The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma

The CXCL10-CXCR3 axis regulates immunity, tumorigenesis, and metastasis in multiple cancers. Yet, its roles in osteosarcoma (OS), the predominant pediatric malignant bone tumor, are not fully defined. Our prior work has shown that elevated serum CXCL10 levels correlate with poor OS prognosis. The cu...

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Bibliographic Details
Main Authors: Benjamin B. Gyau, Junyan Wang, Xiang Chen, Margaret A. Clement, Zoe D. Man, Angela M. Major, Mathew C. Weiser, Jun Xu, John Hicks, Tsz-Kwong Man
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Bone Oncology
Subjects:
Osteosarcoma
Metastasis
CXCR3
CXCL10
AKT
PAK1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137425000314
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