Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer

Abstract Background DNA hypomethylation and uracil misincorporation into DNA, both of which have a very important correlation with colorectal carcinogenesis. Folate plays a crucial role in DNA synthesis, acting as a coenzyme in one-carbon metabolism, which involves the synthesis of purines, pyrimidi...

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Bibliographic Details
Main Authors: Meng Ye, Guojie Xu, Liming Zhang, Zhihui Kong, Zhenhua Qiu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Colorectal cancer
MTHFR
Folate
Meta-analysis
Online Access:https://doi.org/10.1186/s12885-025-13546-w
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