COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE
The high demand for insulin preparations by the population of the country makes it urgent to create domestic bioanalogues for the treatment of diabetes mellitus. The equivalency of the quality, safety and efficacy of the bioanalogue with the reference medicinal preparation registered in Russia is re...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
|
| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/616 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850047132792258560 |
|---|---|
| author | I. N. Urakova K. L. Kryshen O. N. Pozharitskaya M. V. Gavrilin A. N. Shikov M. N. Makarova V. G. Makarov |
| author_facet | I. N. Urakova K. L. Kryshen O. N. Pozharitskaya M. V. Gavrilin A. N. Shikov M. N. Makarova V. G. Makarov |
| author_sort | I. N. Urakova |
| collection | DOAJ |
| description | The high demand for insulin preparations by the population of the country makes it urgent to create domestic bioanalogues for the treatment of diabetes mellitus. The equivalency of the quality, safety and efficacy of the bioanalogue with the reference medicinal preparation registered in Russia is required by authority at the stage of preclinical studies. The aim of the study was to study the interaction of insulin substances of domestic production, including short and long-acting insulin with the insulin receptor in comparison with the reference substances registered in Russia by the surface plasmon resonance method. Comparing the interaction kinetics curves and calculated dissociation constants determined by the surface plasmon resonance method it was confirmed that there are no statistically significant differences between the potentially bioanalogical insulin substances Rosinsulin R, Rosinsulin Glargin and Rosinsulin Aspart (LLC ”Zavod Medsintez”, Russia) and the corresponding substances of registered in Russia medicines. |
| format | Article |
| id | doaj-art-1ce592b7cc1249b699ea5e3caac3a0b9 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-1ce592b7cc1249b699ea5e3caac3a0b92025-08-20T02:54:18ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0103136143616COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCEI. N. Urakova0K. L. Kryshen1O. N. Pozharitskaya2M. V. Gavrilin3A. N. Shikov4M. N. Makarova5V. G. Makarov6St.-Petersburg Institute of PharmacyRMC «HOUSE OF PHARMACY» JSCSt.-Petersburg Institute of PharmacyLLC «Zavod Medsintez»St.-Petersburg Institute of PharmacyRMC «HOUSE OF PHARMACY» JSCRMC «HOUSE OF PHARMACY» JSCThe high demand for insulin preparations by the population of the country makes it urgent to create domestic bioanalogues for the treatment of diabetes mellitus. The equivalency of the quality, safety and efficacy of the bioanalogue with the reference medicinal preparation registered in Russia is required by authority at the stage of preclinical studies. The aim of the study was to study the interaction of insulin substances of domestic production, including short and long-acting insulin with the insulin receptor in comparison with the reference substances registered in Russia by the surface plasmon resonance method. Comparing the interaction kinetics curves and calculated dissociation constants determined by the surface plasmon resonance method it was confirmed that there are no statistically significant differences between the potentially bioanalogical insulin substances Rosinsulin R, Rosinsulin Glargin and Rosinsulin Aspart (LLC ”Zavod Medsintez”, Russia) and the corresponding substances of registered in Russia medicines.https://www.pharmjournal.ru/jour/article/view/616inslulininslulin glargininsulin aspartinsulin receptorsplasmon resonanceassociation constant |
| spellingShingle | I. N. Urakova K. L. Kryshen O. N. Pozharitskaya M. V. Gavrilin A. N. Shikov M. N. Makarova V. G. Makarov COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE Разработка и регистрация лекарственных средств inslulin inslulin glargin insulin aspart insulin receptors plasmon resonance association constant |
| title | COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE |
| title_full | COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE |
| title_fullStr | COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE |
| title_full_unstemmed | COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE |
| title_short | COMPARATIVE STUDY OF INTERACTION OF SOME DOMESTIC HUMAN INSULIN SUBSTANCES AND ITS ANALOGUES WITH INSULIN RECEPTOR BY METHOD OF SURFACE PLASMON RESONANCE |
| title_sort | comparative study of interaction of some domestic human insulin substances and its analogues with insulin receptor by method of surface plasmon resonance |
| topic | inslulin inslulin glargin insulin aspart insulin receptors plasmon resonance association constant |
| url | https://www.pharmjournal.ru/jour/article/view/616 |
| work_keys_str_mv | AT inurakova comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance AT klkryshen comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance AT onpozharitskaya comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance AT mvgavrilin comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance AT anshikov comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance AT mnmakarova comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance AT vgmakarov comparativestudyofinteractionofsomedomestichumaninsulinsubstancesanditsanalogueswithinsulinreceptorbymethodofsurfaceplasmonresonance |