Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature
Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma classically occurring in individuals infected with human immunodeficiency virus (HIV). It has a predilection for the oral cavity and jaw. However, recent case reports have shown this variety of lymphoma in the stomach, lung, nasal ca...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-09-01
|
| Series: | Indian Journal of Neurosurgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/2277-9167.146839 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239061129691136 |
|---|---|
| author | Rama Kumari Badyal Rakesh Kumar Vasishta Nandita Kakkar Devi Prasad Patra Pravin Salunke Amey Savardekar |
| author_facet | Rama Kumari Badyal Rakesh Kumar Vasishta Nandita Kakkar Devi Prasad Patra Pravin Salunke Amey Savardekar |
| author_sort | Rama Kumari Badyal |
| collection | DOAJ |
| description | Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma classically occurring in individuals infected with human immunodeficiency virus (HIV). It has a predilection for the oral cavity and jaw. However, recent case reports have shown this variety of lymphoma in the stomach, lung, nasal cavity, cervical lymph nodes and jejunum in HIV-negative individuals. In this manuscript we report a case of primary PBL of brain in an HIV-negative heterosexual man, who presented with multiple episodes of seizures and hemiparesis. It proved a diagnostic challenge as initial stereotactic brain biopsy showed only few necrotic fragments and possibility of glioblastoma multiforme was rendered. Later patient underwent craniotomy and subsequent histopathology combined with immunohistochemistry led us in making a correct diagnosis of extramedullary PBL. Extensive systemic work up failed to reveal any disease outside the central nervous system. Only single case of primary PBL of brain in HIV-negative individual has been reported until date. To the best of our knowledge, this is the second report to suggest such an association. |
| format | Article |
| id | doaj-art-1ce0d3c87bd14e40a2e8d7b36e56d149 |
| institution | OA Journals |
| issn | 2277-954X 2277-9167 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Neurosurgery |
| spelling | doaj-art-1ce0d3c87bd14e40a2e8d7b36e56d1492025-08-20T02:01:16ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Neurosurgery2277-954X2277-91672014-09-01030317818010.4103/2277-9167.146839Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literatureRama Kumari BadyalRakesh Kumar VasishtaNandita KakkarDevi Prasad Patra0Pravin Salunke1Amey Savardekar2Neurosurgery, Postgraduate Institute of Medical Education and ResearchNeurosurgery, Postgraduate Institute of Medical Education and ResearchNeurosurgery, Postgraduate Institute of Medical Education and ResearchPlasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma classically occurring in individuals infected with human immunodeficiency virus (HIV). It has a predilection for the oral cavity and jaw. However, recent case reports have shown this variety of lymphoma in the stomach, lung, nasal cavity, cervical lymph nodes and jejunum in HIV-negative individuals. In this manuscript we report a case of primary PBL of brain in an HIV-negative heterosexual man, who presented with multiple episodes of seizures and hemiparesis. It proved a diagnostic challenge as initial stereotactic brain biopsy showed only few necrotic fragments and possibility of glioblastoma multiforme was rendered. Later patient underwent craniotomy and subsequent histopathology combined with immunohistochemistry led us in making a correct diagnosis of extramedullary PBL. Extensive systemic work up failed to reveal any disease outside the central nervous system. Only single case of primary PBL of brain in HIV-negative individual has been reported until date. To the best of our knowledge, this is the second report to suggest such an association.http://www.thieme-connect.de/DOI/DOI?10.4103/2277-9167.146839central nervous systemhuman immunodeficiency virus-negativeplasmablatic lymphomaprimary |
| spellingShingle | Rama Kumari Badyal Rakesh Kumar Vasishta Nandita Kakkar Devi Prasad Patra Pravin Salunke Amey Savardekar Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature Indian Journal of Neurosurgery central nervous system human immunodeficiency virus-negative plasmablatic lymphoma primary |
| title | Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature |
| title_full | Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature |
| title_fullStr | Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature |
| title_full_unstemmed | Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature |
| title_short | Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature |
| title_sort | primary plasmablastic lymphoma of the central nervous system in an immunocompetent man a case report and review of literature |
| topic | central nervous system human immunodeficiency virus-negative plasmablatic lymphoma primary |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/2277-9167.146839 |
| work_keys_str_mv | AT ramakumaribadyal primaryplasmablasticlymphomaofthecentralnervoussysteminanimmunocompetentmanacasereportandreviewofliterature AT rakeshkumarvasishta primaryplasmablasticlymphomaofthecentralnervoussysteminanimmunocompetentmanacasereportandreviewofliterature AT nanditakakkar primaryplasmablasticlymphomaofthecentralnervoussysteminanimmunocompetentmanacasereportandreviewofliterature AT deviprasadpatra primaryplasmablasticlymphomaofthecentralnervoussysteminanimmunocompetentmanacasereportandreviewofliterature AT pravinsalunke primaryplasmablasticlymphomaofthecentralnervoussysteminanimmunocompetentmanacasereportandreviewofliterature AT ameysavardekar primaryplasmablasticlymphomaofthecentralnervoussysteminanimmunocompetentmanacasereportandreviewofliterature |