12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis

12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis

Abstract Background Disturbed flow regions in the vasculature are predisposed to endothelial dysfunction and atherosclerotic plaque formation. The enzyme 12/15-lipoxygenase (12/15-LOX, encoded by ALOX15) has emerged as a promising therapeutic target for atherosclerosis. However, the relationship bet...

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Bibliographic Details
Main Authors: Jia Wei Chen, Shi Li Chen, Xin Rui Wu, Xin Yi Shu, Si Yi Tang, He Yuan, You Ran Li, Jin Wei Quan, Shuo Feng, Rui Yan Zhang, Chen Die Yang, Lin Lu, Xiao Qun Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
Atherosclerosis
Disturbed flow
Endothelial dysfunction
12/15-lipoxygenase
Shear stress
Online Access:https://doi.org/10.1186/s10020-025-01297-0
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