ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI
Objective – to study the role of polymorphism (Leu432Val, rs1056836) of the CYP1B1 gene in the development of postmenopausal osteoporosis. Materials and Methods. We studied bone mineral density, gene polymorphism CYP1B1 Leu432Val, as well as the concentration of malondialdehyde in the blood plasma...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2017-03-01
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| Series: | Медицина в Кузбассе |
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| Online Access: | http://mednauki.ru/index.php/MK/article/view/65 |
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| author | Игорь Сергеевич Захаров Вадим Гельевич Мозес Галина Александровна Ушакова Глеб Иванович Колпинский Андрей Николаевич Глушков Людмила Александровна Гордеева Елена Владимировна Рудаева |
| author_facet | Игорь Сергеевич Захаров Вадим Гельевич Мозес Галина Александровна Ушакова Глеб Иванович Колпинский Андрей Николаевич Глушков Людмила Александровна Гордеева Елена Владимировна Рудаева |
| author_sort | Игорь Сергеевич Захаров |
| collection | DOAJ |
| description | Objective – to study the role of polymorphism (Leu432Val, rs1056836) of the CYP1B1 gene in the development of postmenopausal osteoporosis.
Materials and Methods. We studied bone mineral density, gene polymorphism CYP1B1 Leu432Val, as well as the concentration of malondialdehyde in the blood plasma of women of Russian ethnic groups in postmenopausal women living in the Kemerovo region.
Results. In women who have a polymorphic variant of Val/Val gene CYP1B1 the level of bone mineral density of the lumbar vertebrae was lower as compared to individuals with genotypes Leu/Val and Leu/Leu (p = 0,02).
Conclusions. The results of the study can be used in complex prediction of osteoporotic changes and stratification of patients for bone densitometry. |
| format | Article |
| id | doaj-art-1cd7e786001e4e16a21c3073a85406f2 |
| institution | DOAJ |
| issn | 1819-0901 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Медицина в Кузбассе |
| spelling | doaj-art-1cd7e786001e4e16a21c3073a85406f22025-08-20T03:15:17ZrusThe Publishing House Medicine and EnlightenmentМедицина в Кузбассе1819-09012017-03-01161576056ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIИгорь Сергеевич Захаров0Вадим Гельевич Мозес1Галина Александровна Ушакова2Глеб Иванович Колпинский3Андрей Николаевич Глушков4Людмила Александровна Гордеева5Елена Владимировна Рудаева6ФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоИнститут экологии человека СО РАН, г. КемеровоИнститут экологии человека СО РАН, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоObjective – to study the role of polymorphism (Leu432Val, rs1056836) of the CYP1B1 gene in the development of postmenopausal osteoporosis. Materials and Methods. We studied bone mineral density, gene polymorphism CYP1B1 Leu432Val, as well as the concentration of malondialdehyde in the blood plasma of women of Russian ethnic groups in postmenopausal women living in the Kemerovo region. Results. In women who have a polymorphic variant of Val/Val gene CYP1B1 the level of bone mineral density of the lumbar vertebrae was lower as compared to individuals with genotypes Leu/Val and Leu/Leu (p = 0,02). Conclusions. The results of the study can be used in complex prediction of osteoporotic changes and stratification of patients for bone densitometry.http://mednauki.ru/index.php/MK/article/view/65минеральная плотность костиполиморфизм геновCYP1B1 |
| spellingShingle | Игорь Сергеевич Захаров Вадим Гельевич Мозес Галина Александровна Ушакова Глеб Иванович Колпинский Андрей Николаевич Глушков Людмила Александровна Гордеева Елена Владимировна Рудаева ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI Медицина в Кузбассе минеральная плотность кости полиморфизм генов CYP1B1 |
| title | ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI |
| title_full | ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI |
| title_fullStr | ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI |
| title_full_unstemmed | ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI |
| title_short | ROLE OF CYP1B1 GENE POLYMORPHISM IN THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSI |
| title_sort | role of cyp1b1 gene polymorphism in the development of postmenopausal osteoporosi |
| topic | минеральная плотность кости полиморфизм генов CYP1B1 |
| url | http://mednauki.ru/index.php/MK/article/view/65 |
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