In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases

In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases

ABSTRACT The primary degradation pathway for antisense oligonucleotides (ASOs) involves endonuclease and exonuclease‐mediated breakdown. The effect of various chemical modifications on the stability of oligonucleotides has not been systematically investigated. The aim of this study was to develop in...

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Bibliographic Details
Main Authors: Jelena Lovrić, Jingjing Yan, XueQing Li, Tony Karlsborn, Mattias Bood, Anders Dahlén, Constanze Hilgendorf, Deepak Kumar Bhatt
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Pharmacology Research & Perspectives
Subjects:
ASO
metabolic stability
nuclease
Online Access:https://doi.org/10.1002/prp2.70096
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