Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing
IntroductionElderly osteosarcoma patients often face significant postoperative challenges, including high recurrence rates and delayed wound healing. These issues are primarily due to inadequate hemostasis, reactive oxygen species (ROS)-mediated microenvironmental inhibition, and compromised bone re...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1609673/full |
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| author | Qiang Zhang Qiang Zhang Qiang Zhang Qiang Zhang Yu Zhang Yu Zhang Yu Zhang Yu Zhang Hui Chen Hui Chen Hui Chen Hui Chen Lei-Na Sun Lei-Na Sun Lei-Na Sun Lei-Na Sun Bin Zhang Bin Zhang Bin Zhang Bin Zhang Dong-Sheng Yue Dong-Sheng Yue Dong-Sheng Yue Dong-Sheng Yue Chang-Li Wang Chang-Li Wang Chang-Li Wang Chang-Li Wang Zhen-Fa Zhang Zhen-Fa Zhang Zhen-Fa Zhang Zhen-Fa Zhang |
| author_facet | Qiang Zhang Qiang Zhang Qiang Zhang Qiang Zhang Yu Zhang Yu Zhang Yu Zhang Yu Zhang Hui Chen Hui Chen Hui Chen Hui Chen Lei-Na Sun Lei-Na Sun Lei-Na Sun Lei-Na Sun Bin Zhang Bin Zhang Bin Zhang Bin Zhang Dong-Sheng Yue Dong-Sheng Yue Dong-Sheng Yue Dong-Sheng Yue Chang-Li Wang Chang-Li Wang Chang-Li Wang Chang-Li Wang Zhen-Fa Zhang Zhen-Fa Zhang Zhen-Fa Zhang Zhen-Fa Zhang |
| author_sort | Qiang Zhang |
| collection | DOAJ |
| description | IntroductionElderly osteosarcoma patients often face significant postoperative challenges, including high recurrence rates and delayed wound healing. These issues are primarily due to inadequate hemostasis, reactive oxygen species (ROS)-mediated microenvironmental inhibition, and compromised bone regeneration. This study aims to address these challenges by introducing a multifunctional adhesive hydrogel designed for synergistic therapy.MethodsThe hydrogel consists of carboxymethyl chitosan methacryloyl (CMCSMA) and tannic acid (TA), which form a dynamic, crosslinked polymer network capable of rapid tissue adhesion and adaptability to moist wound environments. The hydrogel incorporates ginger vesicles (GVs) loaded with doxorubicin (DOX), offering a dual therapeutic approach. The system facilitates hemostasis through physical barrier formation and activation of coagulation factors, while GVs and DOX provide controlled release for ROS scavenging, reduction of inflammation, and targeted tumor cell elimination.ResultsIn vitro experiments demonstrated the hydrogel’s ability to efficiently remove ROS and promote osteogenic differentiation. In a rat osteosarcoma resection model, the hydrogel significantly shortened hemostasis time compared to conventional sponges, reduced tumor recurrence, and accelerated wound healing.DiscussionThis study presents a multifunctional hydrogel that combines hemostasis, antioxidation, tissue repair, and recurrence prevention. The findings suggest that this integrated therapeutic approach holds substantial potential for clinical application in elderly osteosarcoma treatment, addressing critical postoperative challenges and improving patient outcomes. |
| format | Article |
| id | doaj-art-1cd0e6ff685a44b585bfcc20655ebd18 |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-1cd0e6ff685a44b585bfcc20655ebd182025-08-20T02:09:58ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-06-011310.3389/fbioe.2025.16096731609673Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healingQiang Zhang0Qiang Zhang1Qiang Zhang2Qiang Zhang3Yu Zhang4Yu Zhang5Yu Zhang6Yu Zhang7Hui Chen8Hui Chen9Hui Chen10Hui Chen11Lei-Na Sun12Lei-Na Sun13Lei-Na Sun14Lei-Na Sun15Bin Zhang16Bin Zhang17Bin Zhang18Bin Zhang19Dong-Sheng Yue20Dong-Sheng Yue21Dong-Sheng Yue22Dong-Sheng Yue23Chang-Li Wang24Chang-Li Wang25Chang-Li Wang26Chang-Li Wang27Zhen-Fa Zhang28Zhen-Fa Zhang29Zhen-Fa Zhang30Zhen-Fa Zhang31Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaDepartment of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Lung Cancer Center, Tianjin, ChinaTianjin’s Clinical Research Center for Cancer, Tianjin, ChinaIntroductionElderly osteosarcoma patients often face significant postoperative challenges, including high recurrence rates and delayed wound healing. These issues are primarily due to inadequate hemostasis, reactive oxygen species (ROS)-mediated microenvironmental inhibition, and compromised bone regeneration. This study aims to address these challenges by introducing a multifunctional adhesive hydrogel designed for synergistic therapy.MethodsThe hydrogel consists of carboxymethyl chitosan methacryloyl (CMCSMA) and tannic acid (TA), which form a dynamic, crosslinked polymer network capable of rapid tissue adhesion and adaptability to moist wound environments. The hydrogel incorporates ginger vesicles (GVs) loaded with doxorubicin (DOX), offering a dual therapeutic approach. The system facilitates hemostasis through physical barrier formation and activation of coagulation factors, while GVs and DOX provide controlled release for ROS scavenging, reduction of inflammation, and targeted tumor cell elimination.ResultsIn vitro experiments demonstrated the hydrogel’s ability to efficiently remove ROS and promote osteogenic differentiation. In a rat osteosarcoma resection model, the hydrogel significantly shortened hemostasis time compared to conventional sponges, reduced tumor recurrence, and accelerated wound healing.DiscussionThis study presents a multifunctional hydrogel that combines hemostasis, antioxidation, tissue repair, and recurrence prevention. The findings suggest that this integrated therapeutic approach holds substantial potential for clinical application in elderly osteosarcoma treatment, addressing critical postoperative challenges and improving patient outcomes.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1609673/fullpostoperative osteosarcoma managementginger vesiclesadhesive hydrogeldoxorubicinantioxidation-enhanced bone regenerationtumor recurrence inhibition |
| spellingShingle | Qiang Zhang Qiang Zhang Qiang Zhang Qiang Zhang Yu Zhang Yu Zhang Yu Zhang Yu Zhang Hui Chen Hui Chen Hui Chen Hui Chen Lei-Na Sun Lei-Na Sun Lei-Na Sun Lei-Na Sun Bin Zhang Bin Zhang Bin Zhang Bin Zhang Dong-Sheng Yue Dong-Sheng Yue Dong-Sheng Yue Dong-Sheng Yue Chang-Li Wang Chang-Li Wang Chang-Li Wang Chang-Li Wang Zhen-Fa Zhang Zhen-Fa Zhang Zhen-Fa Zhang Zhen-Fa Zhang Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing Frontiers in Bioengineering and Biotechnology postoperative osteosarcoma management ginger vesicles adhesive hydrogel doxorubicin antioxidation-enhanced bone regeneration tumor recurrence inhibition |
| title | Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing |
| title_full | Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing |
| title_fullStr | Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing |
| title_full_unstemmed | Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing |
| title_short | Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing |
| title_sort | dual functional injectable adhesive hydrogel delivering ginger derived doxorubicin vesicles for osteosarcoma recurrence suppression and post resection wound healing |
| topic | postoperative osteosarcoma management ginger vesicles adhesive hydrogel doxorubicin antioxidation-enhanced bone regeneration tumor recurrence inhibition |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1609673/full |
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