Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys
The experimental data concerning the influence of repeated administration of cyclophosphamide in a total dose of 200 mg/kg on the glutathione metabolism and lipide peroxidation in the liver and kidneys of albino noninbred rats are presented. The possibility of the natural cytoprotection system corre...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/331 |
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| author | V. A. Kashuro S. I. Glushkov L. V. Minaeva T. M. Novikova |
| author_facet | V. A. Kashuro S. I. Glushkov L. V. Minaeva T. M. Novikova |
| author_sort | V. A. Kashuro |
| collection | DOAJ |
| description | The experimental data concerning the influence of repeated administration of cyclophosphamide in a total dose of 200 mg/kg on the glutathione metabolism and lipide peroxidation in the liver and kidneys of albino noninbred rats are presented. The possibility of the natural cytoprotection system correction by the use of cycloflavin was shown. The cytoprotection action mechanisms of the pharmacological agent are discussed. |
| format | Article |
| id | doaj-art-1cd02e922bb54793afc7a3e2ae83f5fc |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-1cd02e922bb54793afc7a3e2ae83f5fc2025-08-20T02:49:35ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01559-102932330Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and KidneysV. A. Kashuro0S. I. Glushkov1L. V. Minaeva2T. M. Novikova3Military Medical Academy, St.PetersburgMilitary Medical Academy, St.PetersburgMilitary Unit No. 20533, MurmanskMilitary Medical Academy, St.PetersburgThe experimental data concerning the influence of repeated administration of cyclophosphamide in a total dose of 200 mg/kg on the glutathione metabolism and lipide peroxidation in the liver and kidneys of albino noninbred rats are presented. The possibility of the natural cytoprotection system correction by the use of cycloflavin was shown. The cytoprotection action mechanisms of the pharmacological agent are discussed.https://www.antibiotics-chemotherapy.ru/jour/article/view/331cyclophosphamideglutathionelipide peroxidationcytoflavin |
| spellingShingle | V. A. Kashuro S. I. Glushkov L. V. Minaeva T. M. Novikova Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys Антибиотики и Химиотерапия cyclophosphamide glutathione lipide peroxidation cytoflavin |
| title | Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys |
| title_full | Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys |
| title_fullStr | Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys |
| title_full_unstemmed | Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys |
| title_short | Experimental Study on Cytoflavin Pharmacological Correction of Cyclophosphamide-Induced Toxic Affections of the Liver and Kidneys |
| title_sort | experimental study on cytoflavin pharmacological correction of cyclophosphamide induced toxic affections of the liver and kidneys |
| topic | cyclophosphamide glutathione lipide peroxidation cytoflavin |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/331 |
| work_keys_str_mv | AT vakashuro experimentalstudyoncytoflavinpharmacologicalcorrectionofcyclophosphamideinducedtoxicaffectionsoftheliverandkidneys AT siglushkov experimentalstudyoncytoflavinpharmacologicalcorrectionofcyclophosphamideinducedtoxicaffectionsoftheliverandkidneys AT lvminaeva experimentalstudyoncytoflavinpharmacologicalcorrectionofcyclophosphamideinducedtoxicaffectionsoftheliverandkidneys AT tmnovikova experimentalstudyoncytoflavinpharmacologicalcorrectionofcyclophosphamideinducedtoxicaffectionsoftheliverandkidneys |