Hormonal interventions in skin wounds – a mini review
Abstract The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuation. Cutaneous wound healing typically consists of four characteristic stages, namely hemostasis, inflammation, proliferation, and remodeling, which are carefully carried...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
|
| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-024-00978-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846165097674702848 |
|---|---|
| author | Zeming Li Rui Ma Jiajun Tan Chunmeng Li Yang Xiao Xudong Qiu Shuo Jin Peng Ouyang Yiping Zhao Xiao Xiang Wang Wu |
| author_facet | Zeming Li Rui Ma Jiajun Tan Chunmeng Li Yang Xiao Xudong Qiu Shuo Jin Peng Ouyang Yiping Zhao Xiao Xiang Wang Wu |
| author_sort | Zeming Li |
| collection | DOAJ |
| description | Abstract The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuation. Cutaneous wound healing typically consists of four characteristic stages, namely hemostasis, inflammation, proliferation, and remodeling, which are carefully carried out by coordinated actions of various cells, cytokines, and hormones. Incoordination of these steps may impede complete and efficient reconstruction and functional recovery of wounds or even lead to worsened outcomes. Hormones, as powerful modulators of organ functions, participate in multiple steps of the wound healing process and play a pivotal role by choreographing the complex interplay of cellular and molecular events. Leveraging the regulatory effects of hormones to enhance the healing process, hormonal therapy has emerged as a promising approach in the clinical treatment of wounds. Current research has focused on determination of the optimal dosages, delivery methods, and combinations of hormonal therapies to maximize their therapeutic benefits while minimizing potential side effects. This review highlights the molecular mechanisms, clinical benefits and side effects of the most commonly used hormones in clinical treatment of wounds. |
| format | Article |
| id | doaj-art-1ccdf2681a7340aba7e6d58c72cf9508 |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-1ccdf2681a7340aba7e6d58c72cf95082024-11-17T12:33:21ZengBMCMolecular Medicine1528-36582024-11-013011710.1186/s10020-024-00978-6Hormonal interventions in skin wounds – a mini reviewZeming Li0Rui Ma1Jiajun Tan2Chunmeng Li3Yang Xiao4Xudong Qiu5Shuo Jin6Peng Ouyang7Yiping Zhao8Xiao Xiang9Wang Wu10College of Bioengineering, Chongqing UniversityCollege of Bioengineering, Chongqing UniversityCollege of Bioengineering, Chongqing UniversityChongqing Yi-Cheng Biotechnology Co., LTDCollege of Bioengineering, Chongqing UniversityThe Affiliated Hospital of Beihua UniversityThe Affiliated Hospital of Beihua UniversityDepartment of General Surgery, The First Affiliated Hospital of Jinan UniversityChina Medical UniversityCollege of Bioengineering, Chongqing UniversityCollege of Bioengineering, Chongqing UniversityAbstract The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuation. Cutaneous wound healing typically consists of four characteristic stages, namely hemostasis, inflammation, proliferation, and remodeling, which are carefully carried out by coordinated actions of various cells, cytokines, and hormones. Incoordination of these steps may impede complete and efficient reconstruction and functional recovery of wounds or even lead to worsened outcomes. Hormones, as powerful modulators of organ functions, participate in multiple steps of the wound healing process and play a pivotal role by choreographing the complex interplay of cellular and molecular events. Leveraging the regulatory effects of hormones to enhance the healing process, hormonal therapy has emerged as a promising approach in the clinical treatment of wounds. Current research has focused on determination of the optimal dosages, delivery methods, and combinations of hormonal therapies to maximize their therapeutic benefits while minimizing potential side effects. This review highlights the molecular mechanisms, clinical benefits and side effects of the most commonly used hormones in clinical treatment of wounds.https://doi.org/10.1186/s10020-024-00978-6Wound healingHormoneGrowth factorsHormonal interventions |
| spellingShingle | Zeming Li Rui Ma Jiajun Tan Chunmeng Li Yang Xiao Xudong Qiu Shuo Jin Peng Ouyang Yiping Zhao Xiao Xiang Wang Wu Hormonal interventions in skin wounds – a mini review Molecular Medicine Wound healing Hormone Growth factors Hormonal interventions |
| title | Hormonal interventions in skin wounds – a mini review |
| title_full | Hormonal interventions in skin wounds – a mini review |
| title_fullStr | Hormonal interventions in skin wounds – a mini review |
| title_full_unstemmed | Hormonal interventions in skin wounds – a mini review |
| title_short | Hormonal interventions in skin wounds – a mini review |
| title_sort | hormonal interventions in skin wounds a mini review |
| topic | Wound healing Hormone Growth factors Hormonal interventions |
| url | https://doi.org/10.1186/s10020-024-00978-6 |
| work_keys_str_mv | AT zemingli hormonalinterventionsinskinwoundsaminireview AT ruima hormonalinterventionsinskinwoundsaminireview AT jiajuntan hormonalinterventionsinskinwoundsaminireview AT chunmengli hormonalinterventionsinskinwoundsaminireview AT yangxiao hormonalinterventionsinskinwoundsaminireview AT xudongqiu hormonalinterventionsinskinwoundsaminireview AT shuojin hormonalinterventionsinskinwoundsaminireview AT pengouyang hormonalinterventionsinskinwoundsaminireview AT yipingzhao hormonalinterventionsinskinwoundsaminireview AT xiaoxiang hormonalinterventionsinskinwoundsaminireview AT wangwu hormonalinterventionsinskinwoundsaminireview |