Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis
Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medic...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/8097965 |
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| _version_ | 1832552620430983168 |
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| author | X. A. Andrade H. E. Fuentes D. M. Oramas H. Mann P. Kovarik |
| author_facet | X. A. Andrade H. E. Fuentes D. M. Oramas H. Mann P. Kovarik |
| author_sort | X. A. Andrade |
| collection | DOAJ |
| description | Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein–Barr virus infection. Lymphoid malignancies of T-cell origin are uncommon in patients with rheumatoid arthirits. Clinical presentation with associated hemophagocytic lymphohistiocyotsis is rare and confers a poor prognosis. This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy. |
| format | Article |
| id | doaj-art-1cc9e554f3534b7f95a8bb57905b3efa |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-1cc9e554f3534b7f95a8bb57905b3efa2025-02-03T05:58:09ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/80979658097965Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid ArthritisX. A. Andrade0H. E. Fuentes1D. M. Oramas2H. Mann3P. Kovarik4Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USADepartment of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USADivision of Pathology, University of Illinois at Chicago, Chicago, IL, USADepartment of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USADepartment of Pathology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USAPatients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein–Barr virus infection. Lymphoid malignancies of T-cell origin are uncommon in patients with rheumatoid arthirits. Clinical presentation with associated hemophagocytic lymphohistiocyotsis is rare and confers a poor prognosis. This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy.http://dx.doi.org/10.1155/2018/8097965 |
| spellingShingle | X. A. Andrade H. E. Fuentes D. M. Oramas H. Mann P. Kovarik Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis Case Reports in Hematology |
| title | Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis |
| title_full | Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis |
| title_fullStr | Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis |
| title_full_unstemmed | Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis |
| title_short | Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis |
| title_sort | iatrogenic t cell lymphoma with associated hemophagocytic lymphohistiocyotsis in a patient with long standing rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2018/8097965 |
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