Neoadjuvant Treatment in Rectal Cancer
A major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2024-10-01
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| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1802334 |
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| author | Srinath Bhradwaj R. Aditya Sarin Shyam Aggarwal Shikha Halder S. Hukku Taha Mustafa Vijay Arora V.K. Malik Shivendra Singh G.V. Rao Avinash Saklani Rajesh Bhojwani Saumitra Rawat C. Selvasekar Purvish M. Parikh |
| author_facet | Srinath Bhradwaj R. Aditya Sarin Shyam Aggarwal Shikha Halder S. Hukku Taha Mustafa Vijay Arora V.K. Malik Shivendra Singh G.V. Rao Avinash Saklani Rajesh Bhojwani Saumitra Rawat C. Selvasekar Purvish M. Parikh |
| author_sort | Srinath Bhradwaj R. |
| collection | DOAJ |
| description | A major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as reducing systemic relapses, thus increasing overall survival. Details of the four key TNT trials are discussed. They pave the way for nonoperative management for patients who achieve clinical complete responses. |
| format | Article |
| id | doaj-art-1cc5f3e4cd3e4e20bf1b2987ed1f893b |
| institution | DOAJ |
| issn | 2278-330X 2278-4306 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj-art-1cc5f3e4cd3e4e20bf1b2987ed1f893b2025-08-20T03:05:39ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062024-10-01130427428010.1055/s-0045-1802334Neoadjuvant Treatment in Rectal CancerSrinath Bhradwaj R.0Aditya Sarin1Shyam Aggarwal2Shikha Halder3S. Hukku4Taha Mustafa5Vijay Arora6V.K. Malik7Shivendra Singh8G.V. Rao9Avinash Saklani10Rajesh Bhojwani11Saumitra Rawat12C. Selvasekar13Purvish M. Parikh14Department of Medical Oncology, Apollo Cancer Institutes, Hyderabad, Telangana, IndiaDepartment of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, IndiaDepartment of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, IndiaDepartment of Radiation Oncology, Sir Ganga Ram Hospital, New Delhi, IndiaDepartment of Radiation Oncology, BLK Max Hospital, New Delhi, IndiaDepartment of Colo Rectal Surgery, Sir Ganga Ram Hospital, New Delhi, IndiaDepartment of Laparoscopic Surgery, Sir Ganga Ram Hospital, New Delhi, IndiaDepartment of Laparoscopic Surgery, Sir Ganga Ram Hospital, New Delhi, IndiaDepartment of GI Oncosurgery, RGCI, New Delhi, IndiaDepartment of Gastrointestinal and Minimally Invasive Surgery, Asian Institute of Gastroenterology, Hyderabad, Telangana, IndiaDepartment of Colorectal Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, IndiaDepartment of Surgical Gastroenterology, Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan, IndiaDepartment of Surgical Gastroenterology, SGRH, New Delhi, IndiaClinical Services and Specialist Surgery, The Christie NHS Foundation Trust, Manchester, United KingdomDepartment of Clinical Hematology, Sri Ram Cancer Center, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, IndiaA major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as reducing systemic relapses, thus increasing overall survival. Details of the four key TNT trials are discussed. They pave the way for nonoperative management for patients who achieve clinical complete responses.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1802334TNTNOMLCCRTSCRT |
| spellingShingle | Srinath Bhradwaj R. Aditya Sarin Shyam Aggarwal Shikha Halder S. Hukku Taha Mustafa Vijay Arora V.K. Malik Shivendra Singh G.V. Rao Avinash Saklani Rajesh Bhojwani Saumitra Rawat C. Selvasekar Purvish M. Parikh Neoadjuvant Treatment in Rectal Cancer South Asian Journal of Cancer TNT NOM LCCRT SCRT |
| title | Neoadjuvant Treatment in Rectal Cancer |
| title_full | Neoadjuvant Treatment in Rectal Cancer |
| title_fullStr | Neoadjuvant Treatment in Rectal Cancer |
| title_full_unstemmed | Neoadjuvant Treatment in Rectal Cancer |
| title_short | Neoadjuvant Treatment in Rectal Cancer |
| title_sort | neoadjuvant treatment in rectal cancer |
| topic | TNT NOM LCCRT SCRT |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1802334 |
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