The evolution of the DLK1-DIO3 imprinted domain in mammals.
A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-06-01
|
| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0060135&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850240542650138624 |
|---|---|
| author | Carol A Edwards Andrew J Mungall Lucy Matthews Edward Ryder Dionne J Gray Andrew J Pask Geoffrey Shaw Jennifer A M Graves Jane Rogers SAVOIR consortium Ian Dunham Marilyn B Renfree Anne C Ferguson-Smith |
| author_facet | Carol A Edwards Andrew J Mungall Lucy Matthews Edward Ryder Dionne J Gray Andrew J Pask Geoffrey Shaw Jennifer A M Graves Jane Rogers SAVOIR consortium Ian Dunham Marilyn B Renfree Anne C Ferguson-Smith |
| author_sort | Carol A Edwards |
| collection | DOAJ |
| description | A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster. |
| format | Article |
| id | doaj-art-1cc56e428ef442bd9ec9265423ddbf3a |
| institution | OA Journals |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2008-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-1cc56e428ef442bd9ec9265423ddbf3a2025-08-20T02:00:50ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852008-06-0166e13510.1371/journal.pbio.0060135The evolution of the DLK1-DIO3 imprinted domain in mammals.Carol A EdwardsAndrew J MungallLucy MatthewsEdward RyderDionne J GrayAndrew J PaskGeoffrey ShawJennifer A M GravesJane RogersSAVOIR consortiumIan DunhamMarilyn B RenfreeAnne C Ferguson-SmithA comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in seven vertebrates determined evolutionary conserved regions common to particular sub-groups and to all vertebrates. The emergence of Dlk1-Dio3 imprinting in eutherians has occurred on the maternally inherited chromosome and is associated with region-specific resistance to expansion by repetitive elements and the local introduction of noncoding transcripts including microRNAs and C/D small nucleolar RNAs. A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0060135&type=printable |
| spellingShingle | Carol A Edwards Andrew J Mungall Lucy Matthews Edward Ryder Dionne J Gray Andrew J Pask Geoffrey Shaw Jennifer A M Graves Jane Rogers SAVOIR consortium Ian Dunham Marilyn B Renfree Anne C Ferguson-Smith The evolution of the DLK1-DIO3 imprinted domain in mammals. PLoS Biology |
| title | The evolution of the DLK1-DIO3 imprinted domain in mammals. |
| title_full | The evolution of the DLK1-DIO3 imprinted domain in mammals. |
| title_fullStr | The evolution of the DLK1-DIO3 imprinted domain in mammals. |
| title_full_unstemmed | The evolution of the DLK1-DIO3 imprinted domain in mammals. |
| title_short | The evolution of the DLK1-DIO3 imprinted domain in mammals. |
| title_sort | evolution of the dlk1 dio3 imprinted domain in mammals |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0060135&type=printable |
| work_keys_str_mv | AT carolaedwards theevolutionofthedlk1dio3imprinteddomaininmammals AT andrewjmungall theevolutionofthedlk1dio3imprinteddomaininmammals AT lucymatthews theevolutionofthedlk1dio3imprinteddomaininmammals AT edwardryder theevolutionofthedlk1dio3imprinteddomaininmammals AT dionnejgray theevolutionofthedlk1dio3imprinteddomaininmammals AT andrewjpask theevolutionofthedlk1dio3imprinteddomaininmammals AT geoffreyshaw theevolutionofthedlk1dio3imprinteddomaininmammals AT jenniferamgraves theevolutionofthedlk1dio3imprinteddomaininmammals AT janerogers theevolutionofthedlk1dio3imprinteddomaininmammals AT savoirconsortium theevolutionofthedlk1dio3imprinteddomaininmammals AT iandunham theevolutionofthedlk1dio3imprinteddomaininmammals AT marilynbrenfree theevolutionofthedlk1dio3imprinteddomaininmammals AT annecfergusonsmith theevolutionofthedlk1dio3imprinteddomaininmammals AT carolaedwards evolutionofthedlk1dio3imprinteddomaininmammals AT andrewjmungall evolutionofthedlk1dio3imprinteddomaininmammals AT lucymatthews evolutionofthedlk1dio3imprinteddomaininmammals AT edwardryder evolutionofthedlk1dio3imprinteddomaininmammals AT dionnejgray evolutionofthedlk1dio3imprinteddomaininmammals AT andrewjpask evolutionofthedlk1dio3imprinteddomaininmammals AT geoffreyshaw evolutionofthedlk1dio3imprinteddomaininmammals AT jenniferamgraves evolutionofthedlk1dio3imprinteddomaininmammals AT janerogers evolutionofthedlk1dio3imprinteddomaininmammals AT savoirconsortium evolutionofthedlk1dio3imprinteddomaininmammals AT iandunham evolutionofthedlk1dio3imprinteddomaininmammals AT marilynbrenfree evolutionofthedlk1dio3imprinteddomaininmammals AT annecfergusonsmith evolutionofthedlk1dio3imprinteddomaininmammals |