Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study
AimThis study aimed to investigate the association between the serum uric acid to creatinine ratio (SUA/Cr) and long-term target vessel events (TVEs) in diabetes mellitus (DM) patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).MethodsFrom July 2009 to August...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1599158/full |
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| author | Penghui Cui Shuting Wang Zherui Zhang Ruihua Wang |
| author_facet | Penghui Cui Shuting Wang Zherui Zhang Ruihua Wang |
| author_sort | Penghui Cui |
| collection | DOAJ |
| description | AimThis study aimed to investigate the association between the serum uric acid to creatinine ratio (SUA/Cr) and long-term target vessel events (TVEs) in diabetes mellitus (DM) patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).MethodsFrom July 2009 to August 2011, a total of 2533 patients with coronary heart disease (CHD) who underwent PCI with DES implantation were enrolled to evaluate the relationship between the SUA/Cr and TVEs during a median follow-up of 29.8 months. Multivariable logistic regression and restricted cubic spline analyses were performed, and subgroup analyses were conducted to explore potential effect modifiers.ResultsThe TVEs were significantly associated with previous male gender (OR=1.58, 95%CI: 1.07~2.32, p=0.021), PCI (OR=3.58, 95% CI: 2.27~5.67, p<0.001),previous stroke(OR=2.19,95%CI:1.24~3.89,p=0.007),triglyceride(OR=1.15, 95%CI:1.06~1.26, p=0.002), length of stent (OR=1.01, 95%CI:1~1.01, p<0.001), and diameter of stent (OR=0.62,95%CI:0.41~0.92,p=0.019). In DM patients, Multivariable logistic regression analyses revealed that higher SUA/Cr was independently associated with a reduced risk of TVEs (adjusted OR=0.72, 95% CI: 0.53–0.97, p=0.031). Restricted cubic spline analysis confirmed a linear inverse relationship between SUA/Cr and TVEs (p for non-linearity=0.782). Subgroup analyses revealed stronger protective effects in non-smokers and non-ST elevation acute coronary syndrome (NSTE-ACS) patients within the DM cohort.ConclusionA higher SUA/Cr is independently associated with a reduced risk of TVEs in DM patients undergoing PCI with DES. SUA/Cr holds promise as a potential prognostic biomarker for risk stratification in DM patients undergoing PCI. |
| format | Article |
| id | doaj-art-1cb8f67380524d2da98a4cabffd832f0 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-1cb8f67380524d2da98a4cabffd832f02025-08-20T03:30:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15991581599158Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective studyPenghui Cui0Shuting Wang1Zherui Zhang2Ruihua Wang3Department of Cardiology, Changzhi People’s Hospital, Changzhi, ChinaDepartment of Endocrinology, Changzhi Medical College, Changzhi, ChinaSchool of Public Health, Jilin University, Changchun, ChinaDepartment of Cardiology, Changzhi People’s Hospital, Changzhi, ChinaAimThis study aimed to investigate the association between the serum uric acid to creatinine ratio (SUA/Cr) and long-term target vessel events (TVEs) in diabetes mellitus (DM) patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).MethodsFrom July 2009 to August 2011, a total of 2533 patients with coronary heart disease (CHD) who underwent PCI with DES implantation were enrolled to evaluate the relationship between the SUA/Cr and TVEs during a median follow-up of 29.8 months. Multivariable logistic regression and restricted cubic spline analyses were performed, and subgroup analyses were conducted to explore potential effect modifiers.ResultsThe TVEs were significantly associated with previous male gender (OR=1.58, 95%CI: 1.07~2.32, p=0.021), PCI (OR=3.58, 95% CI: 2.27~5.67, p<0.001),previous stroke(OR=2.19,95%CI:1.24~3.89,p=0.007),triglyceride(OR=1.15, 95%CI:1.06~1.26, p=0.002), length of stent (OR=1.01, 95%CI:1~1.01, p<0.001), and diameter of stent (OR=0.62,95%CI:0.41~0.92,p=0.019). In DM patients, Multivariable logistic regression analyses revealed that higher SUA/Cr was independently associated with a reduced risk of TVEs (adjusted OR=0.72, 95% CI: 0.53–0.97, p=0.031). Restricted cubic spline analysis confirmed a linear inverse relationship between SUA/Cr and TVEs (p for non-linearity=0.782). Subgroup analyses revealed stronger protective effects in non-smokers and non-ST elevation acute coronary syndrome (NSTE-ACS) patients within the DM cohort.ConclusionA higher SUA/Cr is independently associated with a reduced risk of TVEs in DM patients undergoing PCI with DES. SUA/Cr holds promise as a potential prognostic biomarker for risk stratification in DM patients undergoing PCI.https://www.frontiersin.org/articles/10.3389/fendo.2025.1599158/fulldiabetes mellituscoronary heart diseasetarget vessel eventsserum uric acid to creatinine ratiopercutaneous coronary intervention |
| spellingShingle | Penghui Cui Shuting Wang Zherui Zhang Ruihua Wang Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study Frontiers in Endocrinology diabetes mellitus coronary heart disease target vessel events serum uric acid to creatinine ratio percutaneous coronary intervention |
| title | Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study |
| title_full | Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study |
| title_fullStr | Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study |
| title_full_unstemmed | Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study |
| title_short | Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study |
| title_sort | serum uric acid to creatinine ratio and long term target vessel events in diabetes patients undergoing pci with drug eluting stents implantation a retrospective study |
| topic | diabetes mellitus coronary heart disease target vessel events serum uric acid to creatinine ratio percutaneous coronary intervention |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1599158/full |
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