MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours
CNS tumours occur in both pediatric and adult patients and many of these tumours are associated with poor clinical outcome. Due to a paradigm shift in thinking for the last several years, these tumours are now considered to originate from a small population of stem-like cells within the bulk tumour...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/141793 |
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| _version_ | 1849307212481036288 |
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| author | Neha Garg Thusyanth Vijayakumar David Bakhshinyan Chitra Venugopal Sheila K. Singh |
| author_facet | Neha Garg Thusyanth Vijayakumar David Bakhshinyan Chitra Venugopal Sheila K. Singh |
| author_sort | Neha Garg |
| collection | DOAJ |
| description | CNS tumours occur in both pediatric and adult patients and many of these tumours are associated with poor clinical outcome. Due to a paradigm shift in thinking for the last several years, these tumours are now considered to originate from a small population of stem-like cells within the bulk tumour tissue. These cells, termed as brain tumour initiating cells (BTICs), are perceived to be regulated by microRNAs at the posttranscriptional/translational levels. Proliferation, stemness, differentiation, invasion, angiogenesis, metastasis, apoptosis, and cell cycle constitute some of the significant processes modulated by microRNAs in cancer initiation and progression. Characterization and functional studies on oncogenic or tumour suppressive microRNAs are made possible because of developments in sequencing and microarray techniques. In the current review, we bring recent knowledge of the role of microRNAs in BTIC formation and therapy. Special attention is paid to two highly aggressive and well-characterized brain tumours: gliomas and medulloblastoma. As microRNA seems to be altered in the pathogenesis of many human diseases, “microRNA therapy” may now have potential to improve outcomes for brain tumour patients. In this rapidly evolving field, further understanding of miRNA biology and its contribution towards cancer can be mined for new therapeutic tools. |
| format | Article |
| id | doaj-art-1cb57c012a4143a3969a0fa83d2067f8 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1cb57c012a4143a3969a0fa83d2067f82025-08-20T03:54:51ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/141793141793MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System TumoursNeha Garg0Thusyanth Vijayakumar1David Bakhshinyan2Chitra Venugopal3Sheila K. Singh4McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, CanadaMcMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, CanadaMcMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, CanadaMcMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, CanadaMcMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, CanadaCNS tumours occur in both pediatric and adult patients and many of these tumours are associated with poor clinical outcome. Due to a paradigm shift in thinking for the last several years, these tumours are now considered to originate from a small population of stem-like cells within the bulk tumour tissue. These cells, termed as brain tumour initiating cells (BTICs), are perceived to be regulated by microRNAs at the posttranscriptional/translational levels. Proliferation, stemness, differentiation, invasion, angiogenesis, metastasis, apoptosis, and cell cycle constitute some of the significant processes modulated by microRNAs in cancer initiation and progression. Characterization and functional studies on oncogenic or tumour suppressive microRNAs are made possible because of developments in sequencing and microarray techniques. In the current review, we bring recent knowledge of the role of microRNAs in BTIC formation and therapy. Special attention is paid to two highly aggressive and well-characterized brain tumours: gliomas and medulloblastoma. As microRNA seems to be altered in the pathogenesis of many human diseases, “microRNA therapy” may now have potential to improve outcomes for brain tumour patients. In this rapidly evolving field, further understanding of miRNA biology and its contribution towards cancer can be mined for new therapeutic tools.http://dx.doi.org/10.1155/2015/141793 |
| spellingShingle | Neha Garg Thusyanth Vijayakumar David Bakhshinyan Chitra Venugopal Sheila K. Singh MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours Stem Cells International |
| title | MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours |
| title_full | MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours |
| title_fullStr | MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours |
| title_full_unstemmed | MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours |
| title_short | MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours |
| title_sort | microrna regulation of brain tumour initiating cells in central nervous system tumours |
| url | http://dx.doi.org/10.1155/2015/141793 |
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