Defensin: The immune system regulatory factor against peripheral nerve disease
Abstract Peripheral nerve disease is commonly encountered in orthopedics, neurology, and neurosurgery. Due to its large population, a substantial number of patients are affected by these conditions in China. Peripheral nerve disease has a high disability rate and current treatments show poor clinica...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Brain-X |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brx2.70022 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849737998588968960 |
|---|---|
| author | Tiantian Qi Qi Yang Haotian Qin Yuanchao Zhu Jinyuan Chen Hongfa Zhou Jian Weng Hui Zeng Fei Yu |
| author_facet | Tiantian Qi Qi Yang Haotian Qin Yuanchao Zhu Jinyuan Chen Hongfa Zhou Jian Weng Hui Zeng Fei Yu |
| author_sort | Tiantian Qi |
| collection | DOAJ |
| description | Abstract Peripheral nerve disease is commonly encountered in orthopedics, neurology, and neurosurgery. Due to its large population, a substantial number of patients are affected by these conditions in China. Peripheral nerve disease has a high disability rate and current treatments show poor clinical efficacy, resulting in a heavy burden for patients and the country's healthcare system. Defensins are widespread proteins, commonly found in animals, plants, and fungi, with multiple subtypes able to kill a variety of pathogens. As regulatory factors of the immune system, defensins influence bodily function by participating in inflammatory processes, immune responses, and pathogen resistance; they can affect all stages of nerve conduction and play an important role in lesions of peripheral and effector nerves. This article provides a review of the possible roles and mechanisms of defensins in peripheral nerve disease. |
| format | Article |
| id | doaj-art-1cb0a89ab2aa4c90b66d22ec6dd811e0 |
| institution | DOAJ |
| issn | 2835-3153 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain-X |
| spelling | doaj-art-1cb0a89ab2aa4c90b66d22ec6dd811e02025-08-20T03:06:44ZengWileyBrain-X2835-31532025-03-0131n/an/a10.1002/brx2.70022Defensin: The immune system regulatory factor against peripheral nerve diseaseTiantian Qi0Qi Yang1Haotian Qin2Yuanchao Zhu3Jinyuan Chen4Hongfa Zhou5Jian Weng6Hui Zeng7Fei Yu8Department of Orthopedic Trauma Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Shenzhen Guangdong ChinaDepartment of Ultrasound Medicine Peking University Shenzhen Hospital Shenzhen Guangdong ChinaDepartment of Bone and Joint Surgery Peking University Shenzhen Hospital Shenzhen Guangdong ChinaDepartment of Bone and Joint Surgery Peking University Shenzhen Hospital Shenzhen Guangdong ChinaDepartment of Bone and Joint Surgery Peking University Shenzhen Hospital Shenzhen Guangdong ChinaDepartment of Bone and Joint Surgery Peking University Shenzhen Hospital Shenzhen Guangdong ChinaLife Sciences Institute University of Michigan Ann Arbor Michigan USADepartment of Orthopedic Trauma Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Shenzhen Guangdong ChinaDepartment of Spine Surgery Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Shenzhen Guangdong ChinaAbstract Peripheral nerve disease is commonly encountered in orthopedics, neurology, and neurosurgery. Due to its large population, a substantial number of patients are affected by these conditions in China. Peripheral nerve disease has a high disability rate and current treatments show poor clinical efficacy, resulting in a heavy burden for patients and the country's healthcare system. Defensins are widespread proteins, commonly found in animals, plants, and fungi, with multiple subtypes able to kill a variety of pathogens. As regulatory factors of the immune system, defensins influence bodily function by participating in inflammatory processes, immune responses, and pathogen resistance; they can affect all stages of nerve conduction and play an important role in lesions of peripheral and effector nerves. This article provides a review of the possible roles and mechanisms of defensins in peripheral nerve disease.https://doi.org/10.1002/brx2.70022defensinsfunctional interventionmechanism of actionperipheral nerve diseases |
| spellingShingle | Tiantian Qi Qi Yang Haotian Qin Yuanchao Zhu Jinyuan Chen Hongfa Zhou Jian Weng Hui Zeng Fei Yu Defensin: The immune system regulatory factor against peripheral nerve disease Brain-X defensins functional intervention mechanism of action peripheral nerve diseases |
| title | Defensin: The immune system regulatory factor against peripheral nerve disease |
| title_full | Defensin: The immune system regulatory factor against peripheral nerve disease |
| title_fullStr | Defensin: The immune system regulatory factor against peripheral nerve disease |
| title_full_unstemmed | Defensin: The immune system regulatory factor against peripheral nerve disease |
| title_short | Defensin: The immune system regulatory factor against peripheral nerve disease |
| title_sort | defensin the immune system regulatory factor against peripheral nerve disease |
| topic | defensins functional intervention mechanism of action peripheral nerve diseases |
| url | https://doi.org/10.1002/brx2.70022 |
| work_keys_str_mv | AT tiantianqi defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT qiyang defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT haotianqin defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT yuanchaozhu defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT jinyuanchen defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT hongfazhou defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT jianweng defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT huizeng defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease AT feiyu defensintheimmunesystemregulatoryfactoragainstperipheralnervedisease |