Elastin genetic point mutation and the risk of pelvic organ prolapse
Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exi...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.5100 |
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| author | N. Haya I. Feferkorn F. Fares N. Azzam R. Auslender Y. Abramov |
| author_facet | N. Haya I. Feferkorn F. Fares N. Azzam R. Auslender Y. Abramov |
| author_sort | N. Haya |
| collection | DOAJ |
| description | Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exists between elastin gene polymorphism and POP. Materials and Methods: Patients of Ashkenazi Jewish origin with advanced (stage III-IV) POP (as assessed by POP-Q) and healthy controls were compared for the presence of the elastin gene g28197A > G missense mutation. Results: The missense mutation in the elastin gene was not found in neither the study or the control group. Conclusion: The elastin gene g28197A > G missense mutation was not found to be associated with an increased risk for POP. |
| format | Article |
| id | doaj-art-1cae6dd0255b447f95e88abe541b4f33 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-1cae6dd0255b447f95e88abe541b4f332025-08-20T02:01:45ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-02-01471757810.31083/j.ceog.2020.01.5100S0390-6663(20)00208-0Elastin genetic point mutation and the risk of pelvic organ prolapseN. Haya0I. Feferkorn1F. Fares2N. Azzam3R. Auslender4Y. Abramov5Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Haifa, IsraelDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Haifa, IsraelFaculty of Natural Sciences, University of Haifa, IsraelFaculty of Natural Sciences, University of Haifa, IsraelDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Haifa, IsraelDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion University, Haifa, IsraelAim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exists between elastin gene polymorphism and POP. Materials and Methods: Patients of Ashkenazi Jewish origin with advanced (stage III-IV) POP (as assessed by POP-Q) and healthy controls were compared for the presence of the elastin gene g28197A > G missense mutation. Results: The missense mutation in the elastin gene was not found in neither the study or the control group. Conclusion: The elastin gene g28197A > G missense mutation was not found to be associated with an increased risk for POP.https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.5100elastingenetic polymorphismpelvic organ prolapsepoint mutation |
| spellingShingle | N. Haya I. Feferkorn F. Fares N. Azzam R. Auslender Y. Abramov Elastin genetic point mutation and the risk of pelvic organ prolapse Clinical and Experimental Obstetrics & Gynecology elastin genetic polymorphism pelvic organ prolapse point mutation |
| title | Elastin genetic point mutation and the risk of pelvic organ prolapse |
| title_full | Elastin genetic point mutation and the risk of pelvic organ prolapse |
| title_fullStr | Elastin genetic point mutation and the risk of pelvic organ prolapse |
| title_full_unstemmed | Elastin genetic point mutation and the risk of pelvic organ prolapse |
| title_short | Elastin genetic point mutation and the risk of pelvic organ prolapse |
| title_sort | elastin genetic point mutation and the risk of pelvic organ prolapse |
| topic | elastin genetic polymorphism pelvic organ prolapse point mutation |
| url | https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.5100 |
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