Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study
BackgroundAmputation confers disabilities upon patients and is linked to cardiometabolic morbidity and mortality. We aimed to compare the incidence of type 2 diabetes (T2DM) between individuals following amputation with those of the general population.MethodsWe performed a population-based retrospec...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1437860/full |
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| author | Jung Eun Yoo Jung Eun Yoo Dagyeong Lee Bongseong Kim Won Hyuk Chang Sang-Man Jin Kyungdo Han Dong Wook Shin Dong Wook Shin |
| author_facet | Jung Eun Yoo Jung Eun Yoo Dagyeong Lee Bongseong Kim Won Hyuk Chang Sang-Man Jin Kyungdo Han Dong Wook Shin Dong Wook Shin |
| author_sort | Jung Eun Yoo |
| collection | DOAJ |
| description | BackgroundAmputation confers disabilities upon patients and is linked to cardiometabolic morbidity and mortality. We aimed to compare the incidence of type 2 diabetes (T2DM) between individuals following amputation with those of the general population.MethodsWe performed a population-based retrospective cohort study using the Nationwide Health Insurance Service database. A total of 21,343 individuals with amputation during 2010–2018 and their 1:3 age- and sex-matched controls was included. We conducted Cox proportional hazard analysis to calculate the risk of T2DM among individuals with amputation.ResultsDuring the 4.2 ± 2.5 year mean follow-up period, there were 912 incident T2DM cases (10.7 per 1,000 person-years) among individuals with amputation. Individuals with amputation had a higher risk for T2DM (adjusted hazard ratio [aHR] 1.11, 95% confidence interval [CI] 1.03–1.20) compared with matched controls. The risks were increased further when accompanied with disability; those with severe disability had a higher risk of T2DM (aHR 1.77, 95% CI 1.20–2.60) than matched controls. Individuals with proximal upper limb amputation (aHR 1.10, 95% CI 1.02–1.18) and proximal lower limb amputation (aHR 3.60, 95% CI 1.50–8.64) had a higher risk of T2DM compared with matched controls.ConclusionsIndividuals with amputation were at significantly greater risk for T2DM than the general population, particularly those with severe disability and proximal amputation. Innovative strategies that improve and support the long-term T2DM risk for severely injured individuals with proximal amputation are warranted. |
| format | Article |
| id | doaj-art-1cabe862e7db4413a20a2ab7c91fde71 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-1cabe862e7db4413a20a2ab7c91fde712025-08-20T01:48:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14378601437860Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort studyJung Eun Yoo0Jung Eun Yoo1Dagyeong Lee2Bongseong Kim3Won Hyuk Chang4Sang-Man Jin5Kyungdo Han6Dong Wook Shin7Dong Wook Shin8Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Family Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDivision of Endocrinology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of KoreaDepartment of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of KoreaBackgroundAmputation confers disabilities upon patients and is linked to cardiometabolic morbidity and mortality. We aimed to compare the incidence of type 2 diabetes (T2DM) between individuals following amputation with those of the general population.MethodsWe performed a population-based retrospective cohort study using the Nationwide Health Insurance Service database. A total of 21,343 individuals with amputation during 2010–2018 and their 1:3 age- and sex-matched controls was included. We conducted Cox proportional hazard analysis to calculate the risk of T2DM among individuals with amputation.ResultsDuring the 4.2 ± 2.5 year mean follow-up period, there were 912 incident T2DM cases (10.7 per 1,000 person-years) among individuals with amputation. Individuals with amputation had a higher risk for T2DM (adjusted hazard ratio [aHR] 1.11, 95% confidence interval [CI] 1.03–1.20) compared with matched controls. The risks were increased further when accompanied with disability; those with severe disability had a higher risk of T2DM (aHR 1.77, 95% CI 1.20–2.60) than matched controls. Individuals with proximal upper limb amputation (aHR 1.10, 95% CI 1.02–1.18) and proximal lower limb amputation (aHR 3.60, 95% CI 1.50–8.64) had a higher risk of T2DM compared with matched controls.ConclusionsIndividuals with amputation were at significantly greater risk for T2DM than the general population, particularly those with severe disability and proximal amputation. Innovative strategies that improve and support the long-term T2DM risk for severely injured individuals with proximal amputation are warranted.https://www.frontiersin.org/articles/10.3389/fendo.2024.1437860/fullamputationtraumatype 2 diabetesdisabilityproximal amputation |
| spellingShingle | Jung Eun Yoo Jung Eun Yoo Dagyeong Lee Bongseong Kim Won Hyuk Chang Sang-Man Jin Kyungdo Han Dong Wook Shin Dong Wook Shin Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study Frontiers in Endocrinology amputation trauma type 2 diabetes disability proximal amputation |
| title | Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study |
| title_full | Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study |
| title_fullStr | Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study |
| title_full_unstemmed | Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study |
| title_short | Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study |
| title_sort | increased risk of type 2 diabetes after traumatic amputation a nationwide retrospective cohort study |
| topic | amputation trauma type 2 diabetes disability proximal amputation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1437860/full |
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