The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease
The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enz...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/793505 |
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| _version_ | 1849307901805461504 |
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| author | Ewa Pniewska Rafal Pawliczak |
| author_facet | Ewa Pniewska Rafal Pawliczak |
| author_sort | Ewa Pniewska |
| collection | DOAJ |
| description | The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are involved in inflammation through participation in pro- and anti-inflammatory mediators production and have an impact on many immunocompetent cells. The 30 members of the A2 superfamily are divided into 7 groups. Their role in asthma and COPD has been studied in vitro and in vivo (animal models, cell cultures, and patients). This paper contains complete and updated information about the involvement of particular enzymes in the etiology and course of asthma and COPD. |
| format | Article |
| id | doaj-art-1ca95b148aba49ea99b501ec84f1f829 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1ca95b148aba49ea99b501ec84f1f8292025-08-20T03:54:37ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/793505793505The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary DiseaseEwa Pniewska0Rafal Pawliczak1Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7/9 Zeligowskiego Street, Building 2, Room 122, 90-752 Lodz, PolandDepartment of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7/9 Zeligowskiego Street, Building 2, Room 122, 90-752 Lodz, PolandThe increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are involved in inflammation through participation in pro- and anti-inflammatory mediators production and have an impact on many immunocompetent cells. The 30 members of the A2 superfamily are divided into 7 groups. Their role in asthma and COPD has been studied in vitro and in vivo (animal models, cell cultures, and patients). This paper contains complete and updated information about the involvement of particular enzymes in the etiology and course of asthma and COPD.http://dx.doi.org/10.1155/2013/793505 |
| spellingShingle | Ewa Pniewska Rafal Pawliczak The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease Mediators of Inflammation |
| title | The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease |
| title_full | The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease |
| title_fullStr | The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease |
| title_short | The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease |
| title_sort | involvement of phospholipases a2 in asthma and chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2013/793505 |
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